Noninvasive detection of glucose concentration by differential absorption OCI with two wavelengths

Yao Li; Yonghong He; Xiangsong Dai; Peng Li; Lian Duan; Yong Zhou; Nan Zeng

doi:10.1117/12.843457

28 October 2009 Noninvasive detection of glucose concentration by differential absorption OCI with two wavelengths

Yao Li, Yonghong He, Xiangsong Dai, Peng Li, Lian Duan, Yong Zhou, Nan Zeng

Proceedings Volume 7519, Eighth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2009); 751911 (2009) https://doi.org/10.1117/12.843457
Event: Photonics and Optoelectronics Meetings 2009, 2009, Wuhan, China

Abstract

We present a new method of glucose concentration detection with a differential absorption optical low-coherent interferometry (DAOCI) technique. In our system, we uses two OCI signals recorded by turns in one period with the same detector. Two different light sources are selected corresponding to the different absorption coefficient of the glucose absorption band. The ratio of the two intensities depends on the concentration of the glucose in samples. With the known difference in the absorption cross section or experimental data, it is possible to calculate the mean glucose concentration of samples. In our experiment, we measured a series of glucose solution in a cuvette, and the systemic resolution we got is 16.14mg/dL which achieves the required accuracy(20mg/dL) for practical application. The results prove the feasibility of this method to be used for no-invasive detection of glucose in the aqueous humor.

Citation Download Citation

Yao Li, Yonghong He, Xiangsong Dai, Peng Li, Lian Duan, Yong Zhou, and Nan Zeng "Noninvasive detection of glucose concentration by differential absorption OCI with two wavelengths", Proc. SPIE 7519, Eighth International Conference on Photonics and Imaging in Biology and Medicine (PIBM 2009), 751911 (28 October 2009); https://doi.org/10.1117/12.843457

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