Monitoring small changes in blood hematocrit using phase sensitive spectral domain optical coherence tomography

Venu Gopal Reddy Manne; Ravi Kiran Manapuram; Narendran Sudheendran; Kirill V. Larin

doi:10.1117/12.842289

19 February 2010 Monitoring small changes in blood hematocrit using phase sensitive spectral domain optical coherence tomography

Venu Gopal Reddy Manne, Ravi Kiran Manapuram, Narendran Sudheendran, Kirill V. Larin

Author Affiliations +

Proceedings Volume 7554, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIV; 755424 (2010) https://doi.org/10.1117/12.842289
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

A new method for monitoring ultra-small changes in blood hematocrit (~0.2%) based on measurement of refractive index changes in vitro using Phase Sensitive Spectral Domain Optical Coherence Tomography modality (PhS-SDOCT) is introduced. The developed system has an axial resolution of ~8 μm, phase sensitivity of ±0.01 radians, imaging depth of 3.4 ± 0.01 mm in air, and image acquisition speed of 29 kHz. The experimental accuracy for monitoring refractive index changes as a function of hematocrit level in blood is found to be ±1.5x10^-4 (±0.2%). Obtained results indicate that the PhS-SDOCT can be used to monitor ultra-small changes in the hematocrit and in vitro and, potentially, in tissue blood vessels in vivo.

Citation Download Citation

Venu Gopal Reddy Manne, Ravi Kiran Manapuram, Narendran Sudheendran, and Kirill V. Larin "Monitoring small changes in blood hematocrit using phase sensitive spectral domain optical coherence tomography", Proc. SPIE 7554, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIV, 755424 (19 February 2010); https://doi.org/10.1117/12.842289

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