Effect of laser immunotherapy and surgery on the treatment of mouse mammary tumors

Vivian A. Chen; Henry Le; Xiaosong Li; Roman F. Wolf; Halie Ferguson; Akhee Sarkar; Hong Liu; Robert E. Nordquist; Wei R. Chen

doi:10.1117/12.843231

24 February 2010 Effect of laser immunotherapy and surgery on the treatment of mouse mammary tumors

Vivian A. Chen, Henry Le, Xiaosong Li, Roman F. Wolf, Halie Ferguson, Akhee Sarkar, Hong Liu, Robert E. Nordquist, Wei R. Chen

Author Affiliations +

Proceedings Volume 7565, Biophotonics and Immune Responses V; 756508 (2010) https://doi.org/10.1117/12.843231
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

Laser immunotherapy using laser photothermal therapy and immunological stimulation could achieve tumor-specific immune responses, as indicated by our previous pre-clinical and preliminary clinical studies. To further study the effect of laser immunotherapy, we conducted an investigation combining laser immunotherapy and surgery. After laser immunotherapy, treated tumors were surgically removed at different time points. The survival rates of treated mice were compared among different groups. Furthermore, the cured mice were rechallenged to test the immunity induced by laser immunotherapy. Our results showed that the mice treated with surgical removal one week after laser immunotherapy had the highest survival rate (77%). When the tumors were removed immediately after laser immunotherapy treatment, the survival rate was 57%. Most cured mice withstood tumor rechallenges, indicating an induction of tumor immunity by laser immunotherapy. The differentiations between different surgery groups indicate that the treated tumors have contributed to the immunological responses of the hosts.

Citation Download Citation

Vivian A. Chen, Henry Le, Xiaosong Li, Roman F. Wolf, Halie Ferguson, Akhee Sarkar, Hong Liu, Robert E. Nordquist, and Wei R. Chen "Effect of laser immunotherapy and surgery on the treatment of mouse mammary tumors", Proc. SPIE 7565, Biophotonics and Immune Responses V, 756508 (24 February 2010); https://doi.org/10.1117/12.843231

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