Laser-tissue photobiological interaction: a new mechanism for laser sensitizer immunoadjuvant treatment of metastatic cancers

Wei R. Chen; David A. Okrongly; Robert L. Adams; Robert E. Nordquist

doi:10.1117/12.275492

16 June 1997 Laser-tissue photobiological interaction: a new mechanism for laser sensitizer immunoadjuvant treatment of metastatic cancers

Wei R. Chen, David A. Okrongly, Robert L. Adams, Robert E. Nordquist

Author Affiliations +

Proceedings Volume 2975, Laser-Tissue Interaction VIII; (1997) https://doi.org/10.1117/12.275492
Event: BiOS '97, Part of Photonics West, 1997, San Jose, CA, United States

Abstract

Photophysical reactions have been the focus of laser-tissue interactions. However, these interactions usually have localized and short-term effect, hence only resulting in limited success against systemic lesions, especially against metastatic tumors. Could laser induce a photobiological reaction, specifically a long-term reaction in cancer treatment. Our experimental results on treatment of rat breast cancer indicated that a systemic and long term response against the tumors could be stimulated by a new laser-sensitizer-immunoadjuvant treatment. Long term impact of our method was observed; survival tumor rats and apparent ability against tumor re-challenge. The long term effect was also confirmed by our histochemical studies. Our results pointed to a humoral immune response. A new mechanism of laser-tissue interaction, namely laser-sensitizer- immunoadjuvant induced photobiological reaction, may prove to be crucial in laser cancer treatment.

Citation Download Citation

Wei R. Chen, David A. Okrongly, Robert L. Adams, and Robert E. Nordquist "Laser-tissue photobiological interaction: a new mechanism for laser sensitizer immunoadjuvant treatment of metastatic cancers", Proc. SPIE 2975, Laser-Tissue Interaction VIII, (16 June 1997); https://doi.org/10.1117/12.275492

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