Integrated photoacoustic and fluorescence confocal microscopy

Yu Wang; Konstantin Maslov; Chulhong Kim; Song Hu; Lihong V. Wang

doi:10.1117/12.874888

17 February 2011 Integrated photoacoustic and fluorescence confocal microscopy

Yu Wang, Konstantin Maslov, Chulhong Kim, Song Hu, Lihong V. Wang

Proceedings Volume 7899, Photons Plus Ultrasound: Imaging and Sensing 2011; 78990M (2011) https://doi.org/10.1117/12.874888
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

Optical-resolution photoacoustic microscopy has demonstrated utility in imaging and characterizing microvasculature networks in vivo. This work presents a novel imaging system that integrates optical-resolution photoacoustic microscopy and fluorescence confocal microscopy for simultaneous photoacoustic and fluorescence imaging. The integrated system can acquire intrinsically registered photoacoustic and fluorescence images in a single scan. Capable of providing micrometer scale microscopic imaging of both optical absorption and fluorescence contrasts, the system demonstrates in vivo imaging of oxygen saturation and oxygen partial pressure in mouse ears.

Citation Download Citation

Yu Wang, Konstantin Maslov, Chulhong Kim, Song Hu, and Lihong V. Wang "Integrated photoacoustic and fluorescence confocal microscopy", Proc. SPIE 7899, Photons Plus Ultrasound: Imaging and Sensing 2011, 78990M (17 February 2011); https://doi.org/10.1117/12.874888

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