Noninvasive quantification of metabolic rate of oxygen (MRO2) by photoacoustic microscopy

Junjie Yao; Konstantin I. Maslov; Lihong V. Wang

doi:10.1117/12.874777

17 February 2011 Noninvasive quantification of metabolic rate of oxygen (MRO₂) by photoacoustic microscopy

Junjie Yao, Konstantin I. Maslov, Lihong V. Wang

Proceedings Volume 7899, Photons Plus Ultrasound: Imaging and Sensing 2011; 78990N (2011) https://doi.org/10.1117/12.874777
Event: SPIE BiOS, 2011, San Francisco, California, United States

Abstract

Many diseases, normal decay and physiological functions are closely related to alterations in the metabolic rate of oxygen (MRO₂). In this study, we demonstrate that all the parameters for MRO₂ quantification can be simultaneously obtained by optical-resolution photoacoustic microscopy (OR-PAM). MRO₂ of the mouse ear under normothermia (31 °C skin temperature) and controlled systematic hyperthermia (42 °C skin temperature) was studied. As a result of hyperthermia, the MRO₂ increased by 34.1%. The tumor hypermetabolism was also demonstrated by longitudinally monitoring a melanoma growing on a mouse ear. The results show that OR-PAM, as a single noninvasive imaging modality, is well suited for quantitative MRO₂ measurement in microenvironments.

Citation Download Citation

Junjie Yao, Konstantin I. Maslov, and Lihong V. Wang "Noninvasive quantification of metabolic rate of oxygen (MRO₂) by photoacoustic microscopy", Proc. SPIE 7899, Photons Plus Ultrasound: Imaging and Sensing 2011, 78990N (17 February 2011); https://doi.org/10.1117/12.874777

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