Trapping and dynamic manipulation with magnetomotive photoacoustic imaging of targeted microspheres mimicking metastatic cancer cells trafficking in the vasculature

Chenwei Wei; Jinjun Xia; Ivan Pelivanov; Xiaoge Hu; Xiaohu Gao; Matthew O'Donnell

doi:10.1117/12.909053

23 February 2012 Trapping and dynamic manipulation with magnetomotive photoacoustic imaging of targeted microspheres mimicking metastatic cancer cells trafficking in the vasculature

Chenwei Wei, Jinjun Xia, Ivan Pelivanov, Xiaoge Hu, Xiaohu Gao, Matthew O'Donnell

Author Affiliations +

Proceedings Volume 8223, Photons Plus Ultrasound: Imaging and Sensing 2012; 82231R (2012) https://doi.org/10.1117/12.909053
Event: SPIE BiOS, 2012, San Francisco, California, United States

Abstract

Trapping and manipulation of micro-scale objects mimicking metastatic cancer cells in a flow field have been demonstrated with magnetomotive photoacoustic (mmPA) imaging. Coupled contrast agents combining gold nanorods (15 nm × 50 nm; absorption peak around 730 nm) with 15 nm diameter magnetic nanospheres were targeted to 10 μm polystyrene beads recirculating in a 1.6 mm diameter tube mimicking a human peripheral vessel. Targeted objects were then trapped by an external magnetic field produced by a dual magnet system consisting of two disc magnets separated by 6 cm to form a polarizing field (0.04 Tesla in the tube region) to magnetize the magnetic contrast agents, and a custom designed cone magnet array with a high magnetic field gradient (about 0.044 Tesla/mm in the tube region) producing a strong trapping force to magnetized contrast agents. Results show that polystyrene beads linked to nanocomposites can be trapped at flow rates up to 12 ml/min. It is shown that unwanted background in a photoacoustic image can be significantly suppressed by changing the position of the cone magnet array with respect to the tube, thus creating coherent movement of the trapped objects. This study makes mmPA imaging very promising for differential visualization of metastatic cells trafficking in the vasculature.

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Chenwei Wei, Jinjun Xia, Ivan Pelivanov, Xiaoge Hu, Xiaohu Gao, and Matthew O'Donnell "Trapping and dynamic manipulation with magnetomotive photoacoustic imaging of targeted microspheres mimicking metastatic cancer cells trafficking in the vasculature", Proc. SPIE 8223, Photons Plus Ultrasound: Imaging and Sensing 2012, 82231R (23 February 2012); https://doi.org/10.1117/12.909053

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KEYWORDS

Magnetism

Photoacoustic imaging

Absorption

Cancer

Imaging systems

Blood

Nanoprobes

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