Frequency-resolved measurements of hemodynamic oscillations and quantitative analysis with a novel hemodynamic model

Michele L. Pierro; Angelo Sassaroli; Bertan Hallacoglu; Jana M. Kainerstorfer; Sergio Fantini

doi:10.1117/12.2003873

25 March 2013 Frequency-resolved measurements of hemodynamic oscillations and quantitative analysis with a novel hemodynamic model

Michele L. Pierro, Angelo Sassaroli, Bertan Hallacoglu, Jana M. Kainerstorfer, Sergio Fantini

Author Affiliations +

Proceedings Volume 8578, Optical Tomography and Spectroscopy of Tissue X; 85780C (2013) https://doi.org/10.1117/12.2003873
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

We present frequency-resolved measurements of the amplitude and phase of cerebral hemodynamic oscillations associated with paced breathing and measured with near-infrared spectroscopy on the forehead of a human subject. We have performed measurements at eleven paced breathing frequencies in the range 0.07-0.25 Hz. The resulting frequency spectra of the amplitude and phase of the hemodynamic oscillations were fit with a recently developed hemodynamic model,¹ that was able to reproduce the measured spectra and to determine a number of associated physiological parameters. The parameters measured include the blood transit times in the capillary (0.87 s) and venous (1.0 s) compartments, and the high-pass cutoff frequency of cerebral autoregulation (0.087 Hz). We also illustrate the implications of the new hemodynamic model on the basis of a phasor representation of physiological and hemodynamic oscillations. The combination of frequency-resolved measurements of cerebral hemodynamics and the phasor-based, frequency-domain solution of the new hemodynamic model provides a novel tool for cerebral hemodynamic studies with a potential for assessing a variety of physiological, functional, and pathological conditions.

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Michele L. Pierro, Angelo Sassaroli, Bertan Hallacoglu, Jana M. Kainerstorfer, and Sergio Fantini "Frequency-resolved measurements of hemodynamic oscillations and quantitative analysis with a novel hemodynamic model", Proc. SPIE 8578, Optical Tomography and Spectroscopy of Tissue X, 85780C (25 March 2013); https://doi.org/10.1117/12.2003873

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KEYWORDS

Hemodynamics

Blood

Capillaries

Data modeling

Near infrared spectroscopy

Oxygen

Blood circulation

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