Single-cell photoacoustic thermometry

Liang Gao; Lidai Wang; Chiye Li; Yan Liu; Haixin Ke; Chi Zhang; Lihong V. Wang

doi:10.1117/12.2004063

4 March 2013 Single-cell photoacoustic thermometry

Liang Gao, Lidai Wang, Chiye Li, Yan Liu, Haixin Ke, Chi Zhang, Lihong V. Wang

Proceedings Volume 8581, Photons Plus Ultrasound: Imaging and Sensing 2013; 858118 (2013) https://doi.org/10.1117/12.2004063
Event: SPIE BiOS, 2013, San Francisco, California, United States

Abstract

A novel photoacoustic thermometric method is presented for simultaneously imaging cells and sensing their temperature. With 3 seconds per frame imaging speed, a temperature resolution of 0.2 °C was achieved in a photo-thermal cell heating experiment. Compared to other approaches, the photoacoustic thermometric method has the advantage of not requiring custom-developed temperature-sensitive biosensors. This feature should facilitate the conversion of single-cell thermometry into a routine lab tool and make it accessible to a much broader biological research community.

Citation Download Citation

Liang Gao, Lidai Wang, Chiye Li, Yan Liu, Haixin Ke, Chi Zhang, and Lihong V. Wang "Single-cell photoacoustic thermometry", Proc. SPIE 8581, Photons Plus Ultrasound: Imaging and Sensing 2013, 858118 (4 March 2013); https://doi.org/10.1117/12.2004063

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