Evaluation of non-rigid constrained CT/CBCT registration algorithms for delineation propagation in the context of prostate cancer radiotherapy

Mathieu Rubeaux; Antoine Simon; Khemara Gnep; Jérémy Colliaux; Oscar Acosta; Renaud de Crevoisier; Pascal Haigron

doi:10.1117/12.2004519

8 March 2013 Evaluation of non-rigid constrained CT/CBCT registration algorithms for delineation propagation in the context of prostate cancer radiotherapy

Mathieu Rubeaux, Antoine Simon, Khemara Gnep, Jérémy Colliaux, Oscar Acosta, Renaud de Crevoisier, Pascal Haigron

Author Affiliations +

Proceedings Volume 8671, Medical Imaging 2013: Image-Guided Procedures, Robotic Interventions, and Modeling; 867106 (2013) https://doi.org/10.1117/12.2004519
Event: SPIE Medical Imaging, 2013, Lake Buena Vista (Orlando Area), Florida, United States

Abstract

Image-Guided Radiation Therapy (IGRT) aims at increasing the precision of radiation dose delivery. In the context of prostate cancer, a planning Computed Tomography (CT) image with manually defined prostate and organs at risk (OAR) delineations is usually associated with daily Cone Beam Computed Tomography (CBCT) follow-up images. The CBCT images allow to visualize the prostate position and to reposition the patient accordingly. They also should be used to evaluate the dose received by the organs at each fraction of the treatment. To do so, the first step is a prostate and OAR segmentation on the daily CBCTs, which is very timeconsuming. To simplify this task, CT to CBCT non-rigid registration could be used in order to propagate the original CT delineations in the CBCT images. For this aim, we compared several non-rigid registration methods. They are all based on the Mutual Information (MI) similarity measure, and use a BSpline transformation model. But we add different constraints to this global scheme in order to evaluate their impact on the final results. These algorithms are investigated on two real datasets, representing a total of 70 CBCT on which a reference delineation has been realized. The evaluation is led using the Dice Similarity Coefficient (DSC) as a quality criteria. The experiments show that a rigid penalty term on the bones improves the final registration result, providing high quality propagated delineations.

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Mathieu Rubeaux, Antoine Simon, Khemara Gnep, Jérémy Colliaux, Oscar Acosta, Renaud de Crevoisier, and Pascal Haigron "Evaluation of non-rigid constrained CT/CBCT registration algorithms for delineation propagation in the context of prostate cancer radiotherapy", Proc. SPIE 8671, Medical Imaging 2013: Image-Guided Procedures, Robotic Interventions, and Modeling, 867106 (8 March 2013); https://doi.org/10.1117/12.2004519

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