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We describe an affordable, harmless, and administrative (AHA) metabolic biomarker (MBM) for homecare
cancer screening. It may save hundreds of thousands of women’s and thousands of men’s lives every year
from breast cancer and melanoma. The goal is to increase the specificity of infrared (IR) imagery to reduce
the false alarm rate (FAR). The patient’s hands are immersed in icy cold water, about 11oC, for 30 seconds.
We then compare two IR images, taken before and after the cold stimulus, and the difference reveals an
enhanced signal and noise ratio (SNR) at tumorigenesis sites since the contraction of capillaries under cold
challenge is natural to healthy capillaries, except those newly built capillaries during angiogenesis (Folkman,
Nature 1995). Concomitant with the genome and the phenome (molecular signaling by phosphor-mediate
protein causing inflammation by platelet activating factor (PAF) that transform cells from benign to
malignant is the amplification of nitric oxide (NO) syntheses, a short-lived reactive oxygen species (ROS)
that dilates regional blood vessels; superseding normal autonomic nervous system regulation. A rapidly
growing tumor site might implicate accumulation of ROS, for which NO can rapidly stretch the capillary bed
system usually having thinning muscular lining known as Neo-Angiogenesis (NA) that could behave like
Leaky In-situ Faucet Effect (LIFE) in response to cold challenge.
To emphasize the state of art knowledge of NA, we mentioned in passing the first generation of an anticapillary
growth drug, Avastin by Genetech; it is an antibody protein that is injected for metastasis, while the
second generation drug; Sorafenib by Bayers (2001) and Sutent by Pfizer (2000) both target molecular
signaling loci to block receptor associated tyrosine kinase induced protein phosphorylation in order to reverse
the angiogenesis.
Differentiating benign from malignant in a straightforward manner is required to achieve the wellness
protocol, yet would become prohibitively expensive and impossible to follow through. For example, given
the probability of detection (PD) about 0.1% over unspecified number of years (e.g. menopause years for
breast cancer), one might need hundred thousand volunteers. We suggested a Time Reversal Invariant
Paradigm (TRIP) (a private communication with Vatican) for gathering equivalent cancer symptom imagery
from recovery histories of dozens of patients. We further mixed it with few % of recovered/non-sick cases for
negative controls. Creating Virtual images and running videos of these, frame by frame, in two directions
(forward and backward in time) resulted in identical Receiver Operation Characteristics (ROC) for both the
computer Aided Target Recognition (AiTR) algorithm and the human radiological experts; namely PD versus
FAR within the standard deviation; even though the physiology could be entirely different. Such a TRIP
would be true taken by any memory-less instantaneous imagery devices (IR, ultrasound, X-rays, MRI
excluding magnetic hysteresis memory).
In summary, such an affordable, harmless, and administrative, neo-angiogenesis metabolic biomarker can
help monitor the transitioning from benign to malignant states of high-risk home alone seniors and also
monitor the progress of home alone seniors treatment at home. Therefore, Smartphone equipped with a day
camera having IR spectral filtering for a contact self imaging called joystick, when augmented with AHA NA
MBM, may be suited for HAS homecare.
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