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7 March 2022 Highly integrated clinical-grade probe for trimodal endoscopic imaging of human bladder
Gerardo E. González-Cerdas, Simon M. Kretschmer, Caglar Ataman, Hans Zappe, Sven Flämig, Karl Reichwald, Gregor Matz, Bernhard Messerschmidt, Ines Latka, Florian Windirsch, Iwan Schie, Jürgen Popp, Okan Ülgen, Christian M. Zakian Dominguez, Vasilis Ntziachristos, Christoph Bauer, Dragan Sandic, Fabian Placzek, Lara Wurster, Rainer Leitgeb, Wolfgang Drexler
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Proceedings Volume PC11937, Endoscopic Microscopy XVII; PC1193707 (2022) https://doi.org/10.1117/12.2609608
Event: SPIE BiOS, 2022, San Francisco, California, United States
Abstract
This work presents the design and implementation of an endoscopic probe for point-of-care diagnosis of bladder cancer, with an outer diameter of 4.5 mm that allows for in-vivo usage. This triple-modality device can deliver volumetric OCT images, optoacoustic tomograms, and single point Raman spectroscopy that target complementary biomarkers. The probe features a piezo-based fiber scanner, which delivers the illumination or excitation light for all modalities, with a maximum Field of View of 1.6 mm. The same path is used for light collection for OCT imaging. A separate fiber is used for detection of the Raman signals, while two additional fibers with microcavity tips sense the ultrasonic waves for optoacoustic tomography. A hyperchromatic micro-optical objective provides a working distance optimized for each modality. The probe housing is produced by selective laser-induced etching of fused silica.
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Gerardo E. González-Cerdas, Simon M. Kretschmer, Caglar Ataman, Hans Zappe, Sven Flämig, Karl Reichwald, Gregor Matz, Bernhard Messerschmidt, Ines Latka, Florian Windirsch, Iwan Schie, Jürgen Popp, Okan Ülgen, Christian M. Zakian Dominguez, Vasilis Ntziachristos, Christoph Bauer, Dragan Sandic, Fabian Placzek, Lara Wurster, Rainer Leitgeb, and Wolfgang Drexler "Highly integrated clinical-grade probe for trimodal endoscopic imaging of human bladder", Proc. SPIE PC11937, Endoscopic Microscopy XVII, PC1193707 (7 March 2022); https://doi.org/10.1117/12.2609608
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KEYWORDS
Endoscopy
Bladder
Optical coherence tomography
Raman spectroscopy
Optoacoustics
Silica
Tissues
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