Effects of voluntary exercise on cerebral microvascular oxygenation in aged mice

Paul Shin; Qi Pian; Hidehiro Ishikawa; Gen Hamanaka; Emiri T. Mandeville; Guo Shuzhen; Buyin Fu; Mohammed Alfadhel; Ikbal Sencan; Baoqiang Li; Chongzhao Ran; Sergei A. Vinogradov; Eng H. Lo; Ken Arai; Anna Devor; Sava Sakadžic

doi:10.1117/12.2610303

28 April 2022 Effects of voluntary exercise on cerebral microvascular oxygenation in aged mice

Paul Shin, Qi Pian, Hidehiro Ishikawa, Gen Hamanaka, Emiri T. Mandeville, Guo Shuzhen, Buyin Fu, Mohammed Alfadhel, Ikbal Sencan, Baoqiang Li, Chongzhao Ran, Sergei A. Vinogradov, Eng H. Lo, Ken Arai, Anna Devor, Sava Sakadžic

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Proceedings Volume PC11946, Neural Imaging and Sensing 2022; PC119460S (2022) https://doi.org/10.1117/12.2610303
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Although the beneficial effects of regular physical exercise on brain aging and neurodegenerative diseases are well recognized, a clear understanding of how exercise leads to such benefits remains elusive. In this work, we investigated the effects of normal aging on cortical microvascular oxygenation, perfusion, and morphology and the impact of four months of voluntary wheel running on cortical microvascular oxygenation in 20 months old mice. We used two-photon microscopy to assess age-related and exercise-induced changes in the distributions of capillary oxygen partial pressure (PO2) and red-blood-cell flux across cortical depth in awake mice. Our finding suggests the mitigating effect of exercise on the progression of age-related changes in capillary oxygenation in deeper cortical layers which may be related to health-enhancing benefits of exercise in elderly individuals.

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Paul Shin, Qi Pian, Hidehiro Ishikawa, Gen Hamanaka, Emiri T. Mandeville, Guo Shuzhen, Buyin Fu, Mohammed Alfadhel, Ikbal Sencan, Baoqiang Li, Chongzhao Ran, Sergei A. Vinogradov, Eng H. Lo, Ken Arai, Anna Devor, and Sava Sakadžic "Effects of voluntary exercise on cerebral microvascular oxygenation in aged mice", Proc. SPIE PC11946, Neural Imaging and Sensing 2022, PC119460S (28 April 2022); https://doi.org/10.1117/12.2610303

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KEYWORDS

Capillaries

Brain

Oxygen

Two photon excitation microscopy

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