Crucial considerations in designing a fiber-based speckle contrast optical tomography for neuroimaging in humans

Chen-Hao P. Lin; Inema E. Orukari; Lisa Kobayashi Frisk; Manish Verma; Sumana Chetia; Adam T. Eggebrecht; Turgut Durduran; Joseph P. Culver; Jason W. Trobaugh

doi:10.1117/12.2650680

17 March 2023 Crucial considerations in designing a fiber-based speckle contrast optical tomography for neuroimaging in humans

Chen-Hao P. Lin, Inema E. Orukari, Lisa Kobayashi Frisk, Manish Verma, Sumana Chetia, Adam T. Eggebrecht, Turgut Durduran, Joseph P. Culver, Jason W. Trobaugh

Author Affiliations +

Proceedings Volume PC12365, Neural Imaging and Sensing 2023; PC1236504 (2023) https://doi.org/10.1117/12.2650680
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

High-Density Speckle Contrast Optical Tomography (HD-SCOT) is an optical technique with the potential to address the limitations of current techniques for imaging Cerebral Blood Flow (CBF). To evaluate HD-SCOT’s performance, we developed an anatomical-head-based simulation to obtain HD-SCOT measurements and reconstructed images. We observed that including longer source-detector distances can reduce localization errors. Even though speckle contrast decreases with increased exposure times, the System-to-Noise Ratio (SNR) can increase dramatically. For instrumentation, we evaluated statistics of speckles through a multi-mode fiber (MMF) bundle and demonstrated the feasibility of tracking pulsatile blood flow in a human subject using MMFs.

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Chen-Hao P. Lin, Inema E. Orukari, Lisa Kobayashi Frisk, Manish Verma, Sumana Chetia, Adam T. Eggebrecht, Turgut Durduran, Joseph P. Culver, and Jason W. Trobaugh "Crucial considerations in designing a fiber-based speckle contrast optical tomography for neuroimaging in humans", Proc. SPIE PC12365, Neural Imaging and Sensing 2023, PC1236504 (17 March 2023); https://doi.org/10.1117/12.2650680

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