Transcutaneous monitoring of oxygen and carbon dioxide using wearable devices

Juan Pedro Cascales Sandoval; Emmanuel Roussakis; Xiaolei Li; Daniel Greenfield; Lilian Witthauer; Avery Goss; Helen Keshishian; John Q. Nguyen; Haley L. Marks; Adina E. Draghici; Jason W. Hamner; J. Andrew Taylor; Conor L. Evans

doi:10.1117/12.2649855

6 March 2023 Transcutaneous monitoring of oxygen and carbon dioxide using wearable devices

Juan Pedro Cascales Sandoval, Emmanuel Roussakis, Xiaolei Li, Daniel Greenfield, Lilian Witthauer, Avery Goss, Helen Keshishian, John Q. Nguyen, Haley L. Marks, Adina E. Draghici, Jason W. Hamner, J. Andrew Taylor, Conor L. Evans

Author Affiliations +

Proceedings Volume PC12375, Biophotonics in Exercise Science, Sports Medicine, Health Monitoring Technologies, and Wearables IV; PC1237503 (2023) https://doi.org/10.1117/12.2649855
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

We present the creation of wearable devices that measure transcutaneous partial oxygen or carbon dioxide pressure (tcpO2 or tcpCO2) non-invasively. The devices are highly sensitive to the physiological pO2/pCO2, and detects changes in luminescence (lifetime or ratiometric brightness) of mellaporphyrins or HPTS dye molecules embedded within breathable, hydrophobic films. Our first in human measurements reveal the devices are able to detect quick and subtle changes in tcpO2 due to local and systemic changes in blood flow of skin or deeper muscle tissue. Models to extract tissue oxygenation and oxygen consumption rate are explored.

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Juan Pedro Cascales Sandoval, Emmanuel Roussakis, Xiaolei Li, Daniel Greenfield, Lilian Witthauer, Avery Goss, Helen Keshishian, John Q. Nguyen, Haley L. Marks, Adina E. Draghici, Jason W. Hamner, J. Andrew Taylor, and Conor L. Evans "Transcutaneous monitoring of oxygen and carbon dioxide using wearable devices", Proc. SPIE PC12375, Biophotonics in Exercise Science, Sports Medicine, Health Monitoring Technologies, and Wearables IV, PC1237503 (6 March 2023); https://doi.org/10.1117/12.2649855

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KEYWORDS

Oxygen

Blood circulation

Carbon dioxide

Skin

Tissues

Natural surfaces

Phosphorescence

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