We present the creation of wearable devices that measure transcutaneous partial oxygen or carbon dioxide pressure (tcpO2 or tcpCO2) non-invasively. The devices are highly sensitive to the physiological pO2/pCO2, and detects changes in luminescence (lifetime or ratiometric brightness) of mellaporphyrins or HPTS dye molecules embedded within breathable, hydrophobic films. Our first in human measurements reveal the devices are able to detect quick and subtle changes in tcpO2 due to local and systemic changes in blood flow of skin or deeper muscle tissue. Models to extract tissue oxygenation and oxygen consumption rate are explored.
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