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In vivo imaging of blood flow is the key for mapping circulatory system function. While photoacoustic computed tomography (PACT) is well-established for imaging deep blood vessels, its feasibility for measuring blood flow beyond the optical diffusion limit (one millimeter) has not been demonstrated. Herein, we report, to our knowledge, the first use of PACT to image deep blood flow in humans. We achieved a penetration depth greater than five millimeters and obtained both the speed and direction as a vector flow map. This work establishes PACT as a powerful tool to study the rich contrast of blood and its hemodynamics.
Yang Zhang,Joshua Olick-Gibson,Anjul Khadria, andLihong V. Wang
"Photoacoustic vector tomography for deep hemodynamic imaging", Proc. SPIE PC12379, Photons Plus Ultrasound: Imaging and Sensing 2023, PC123790K (9 March 2023); https://doi.org/10.1117/12.2655420
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Yang Zhang, Joshua Olick-Gibson, Anjul Khadria, Lihong V. Wang, "Photoacoustic vector tomography for deep hemodynamic imaging," Proc. SPIE PC12379, Photons Plus Ultrasound: Imaging and Sensing 2023, PC123790K (9 March 2023); https://doi.org/10.1117/12.2655420