Photoacoustic imaging reveals differences in perfusion-limited hypoxia in murine breast cancer models

Lina Hacker; Thomas R. Else; Thierry L. Lefebvre; Paul W. Sweeney; Emma L. Brown; Sarah E. Bohndiek

doi:10.1117/12.2649357

9 March 2023 Photoacoustic imaging reveals differences in perfusion-limited hypoxia in murine breast cancer models

Lina Hacker, Thomas R. Else, Thierry L. Lefebvre, Paul W. Sweeney, Emma L. Brown, Sarah E. Bohndiek

Proceedings Volume PC12379, Photons Plus Ultrasound: Imaging and Sensing 2023; PC123791E (2023) https://doi.org/10.1117/12.2649357
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Here, we assess the capabilities of photoacoustic imaging (PAI) biomarkers to shed light into perfusion-limited hypoxia, a key driver of tumor malignancy. Using two breast cancer xenograft models, we found that photoacoustic tomography could detect higher fluctuations in oxygen saturation (sO2MSOT) in models with higher disease aggressiveness, supported by an overall lower sO2MSOT and greater spatial heterogeneity in sO2MSOT. Photoacoustic mesoscopy revealed differences in vascular architecture and perfusion dynamics between the models. The results were validated using immunohistochemistry and RNA sequencing, highlighting the potential of PAI to provide non-invasive insight on dynamic phenomena associated with perfusion-limited hypoxia in vivo.

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Citation Download Citation

Lina Hacker, Thomas R. Else, Thierry L. Lefebvre, Paul W. Sweeney, Emma L. Brown, and Sarah E. Bohndiek "Photoacoustic imaging reveals differences in perfusion-limited hypoxia in murine breast cancer models", Proc. SPIE PC12379, Photons Plus Ultrasound: Imaging and Sensing 2023, PC123791E (9 March 2023); https://doi.org/10.1117/12.2649357

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KEYWORDS

Hypoxia

Tumors

Breast cancer

Photoacoustic imaging

Tumor growth modeling

Optoacoustics

Inflammation

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