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17 March 2023 Improving the sensitivity of fluorescence-based immunoassays by time-resolved and spatial-resolved measurements (Conference Presentation)
Ran Kremer, Shira Roth, Avital Bross, Yair Noam, Amos Danielli
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Proceedings Volume PC12397, Frontiers in Biological Detection: From Nanosensors to Systems XV; PC1239704 (2023) https://doi.org/10.1117/12.2657626
Event: SPIE BiOS, 2023, San Francisco, California, United States
Abstract
In fluorescence-based biosensing applications, to increase optical detection sensitivity, time-resolved measurements are extensively used. Magnetic modulation biosensing (MMB) is a novel, fast, and sensitive detection technology for various applications. While this technology provides high sensitivity detection of biomarkers, to date, only the time resolved signal was analyzed. Here, we use for the first time both time-resolved and spatial-resolved measurements and show that this combination drastically improves the sensitivity of an MMB-based assay.
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Ran Kremer, Shira Roth, Avital Bross, Yair Noam, and Amos Danielli "Improving the sensitivity of fluorescence-based immunoassays by time-resolved and spatial-resolved measurements (Conference Presentation)", Proc. SPIE PC12397, Frontiers in Biological Detection: From Nanosensors to Systems XV, PC1239704 (17 March 2023); https://doi.org/10.1117/12.2657626
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KEYWORDS
Molecules
Signal detection
Target detection
Magnetism
Modulation
Molecular aggregates
Molecular lasers
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