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17 March 2023 Recent advances in rapid and highly sensitive detection of proteins and specific DNA sequences using a magnetic modulation biosensing system (Conference Presentation)
Shira Roth, Michael Margulis, Amos Danielli
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Proceedings Volume PC12397, Frontiers in Biological Detection: From Nanosensors to Systems XV; PC1239705 (2023) https://doi.org/10.1117/12.2652620
Event: SPIE BiOS, 2023, San Francisco, California, United States
Abstract
In early disease stages, biomolecules of interest exist in very low concentrations, presenting a significant challenge for analytical devices and methods. Here, we provide a comprehensive overview of an innovative optical biosensing technology, termed magnetic modulation biosensing (MMB), its biomedical applications, and its ongoing development. In MMB, magnetic beads are attached to fluorescently labeled target molecules. A controlled magnetic force aggregates the magnetic beads and transports them in and out of an excitation laser beam, generating a periodic fluorescent signal that is detected and demodulated. MMB applications include rapid and highly sensitive detection of specific nucleic acid sequences, antibodies, proteins, and protein interactions. Compared with other established analytical methodologies, MMB provides improved sensitivity, shorter processing time, and simpler protocols.
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Shira Roth, Michael Margulis, and Amos Danielli "Recent advances in rapid and highly sensitive detection of proteins and specific DNA sequences using a magnetic modulation biosensing system (Conference Presentation)", Proc. SPIE PC12397, Frontiers in Biological Detection: From Nanosensors to Systems XV, PC1239705 (17 March 2023); https://doi.org/10.1117/12.2652620
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KEYWORDS
Magnetism
Biosensing
Proteins
Modulation
Signal detection
Biomedical optics
Biological research
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