Synergistic killing of Staphylococcus aureus by the combination of cold atmospheric plasma and antimicrobial blue light

Gizem Dilara Ozdemir; Carolina dos Anjos; Utku Kursat Ercan; Tianhong Dai

doi:10.1117/12.3001824

22 March 2024 Synergistic killing of Staphylococcus aureus by the combination of cold atmospheric plasma and antimicrobial blue light

Gizem Dilara Ozdemir, Carolina dos Anjos, Utku Kursat Ercan, Tianhong Dai

Author Affiliations +

Proceedings Volume PC12822, Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2024; PC128220U (2024) https://doi.org/10.1117/12.3001824
Event: SPIE BiOS, 2024, San Francisco, California, United States

Conference Poster

Abstract

This study investigated the potential of an innovative combinational therapy utilizing antimicrobial blue light (aBL) and cold atmospheric plasma (CAP) against Staphylococcus aureus, a clinically challenging gram-positive bacterium. For planktonic S. aureus, sequential treatment (1-3 min CAP followed by 270 J/cm2 aBL) demonstrated an increase of 3- to 6- log10CFU reduction compared to aBL alone, while simultaneous treatment (concurrent 90 J/cm2 aBL and 25 min CAP) led to an increase of 7-log10CFU reduction. For biofilms, a remarkable CFU reduction of 6.5- to 7- log10 was observed for sequential treatment (3-5 min CAP followed by 432 J/cm2 aBL) and a 3-log10CFU reduction for simultaneous treatment (concurrent application 108 J/cm2 aBL and 30 min CAP). These findings highlight the unprecedented efficacy of the aBL + CAP combinational therapy in enhancing the potency against S. aureus, offering a promising approach to overcome antibiotic resistance.

Citation Download Citation

Gizem Dilara Ozdemir, Carolina dos Anjos, Utku Kursat Ercan, and Tianhong Dai "Synergistic killing of Staphylococcus aureus by the combination of cold atmospheric plasma and antimicrobial blue light", Proc. SPIE PC12822, Photonic Diagnosis, Monitoring, Prevention, and Treatment of Infections and Inflammatory Diseases 2024, PC128220U (22 March 2024); https://doi.org/10.1117/12.3001824

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