Diffuse correlation spectroscopy is a widely used optical technique for recovery of blood flow. Its applications have included monitoring of ischemia, blood flow in tumors, and cerebral blood flow. Recently, several variants on this technology have been developed with potential to enhance sensitivity to deep tissues, increase signal-to-noise ratio, and lower costs. Here, we employ diffuse correlation spectroscopy, speckle contrast optical spectroscopy, and interferometric diffusing wave spectroscopy concurrently to measure in vivo and in vitro flow. The results elucidate the advantages and disadvantages of each modality and will aid researchers in selecting a blood flow monitoring method for specific applications.
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