Enhancing vascular imaging using NIR-II fluorescent nanoprobes

Bryce Dunn; Sofya Osharovich; Ritesh Isuri; Wendy Chung; Sébastien Blais-Ouellette; Edward J. Delikatny; John R. Cressman; Remi Veneziano; Parag Chitnis; Marzieh Hanafi

doi:10.1117/12.3003068

13 March 2024 Enhancing vascular imaging using NIR-II fluorescent nanoprobes

Bryce Dunn, Sofya Osharovich, Ritesh Isuri, Wendy Chung, Sébastien Blais-Ouellette, Edward J. Delikatny, John R. Cressman, Remi Veneziano, Parag Chitnis, Marzieh Hanafi

Author Affiliations +

Proceedings Volume PC12862, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XV; PC128620C (2024) https://doi.org/10.1117/12.3003068
Event: SPIE BiOS, 2024, San Francisco, California, United States

Abstract

Fluorescence imaging has emerged as a valuable tool for clinical angiographic and cardiovascular imaging, allowing for visualization and quantification of biological processes. Among the range of fluorescence imaging windows, near-infrared (NIR) imaging has shown great promise as a non-invasive modality for angiographic and cardiovascular imaging. To overcome limitations associated with indocyanine green dye (ICG), we developed a biocompatible DNA-based platform for conjugation with ICG dyes and targeting moieties. The primary objective of this pilot study is to evaluate the efficacy of the DNA-ICG platform for contrast-enhanced NIR-II (>1250 nm) fluorescence imaging in a mouse model. Throughout the experiment, various organs were observed, including the heart, liver, spleen, caecum, and intestines. Notably, vascular structures in the tail, spinal column, and head remained visible for hours after the administration of the contrast agent. The DNA-ICG platform holds promise as an effective imaging tool for angiographic and cardiovascular studies.

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Bryce Dunn, Sofya Osharovich, Ritesh Isuri, Wendy Chung, Sébastien Blais-Ouellette, Edward J. Delikatny, John R. Cressman, Remi Veneziano, Parag Chitnis, and Marzieh Hanafi "Enhancing vascular imaging using NIR-II fluorescent nanoprobes", Proc. SPIE PC12862, Reporters, Markers, Dyes, Nanoparticles, and Molecular Probes for Biomedical Applications XV, PC128620C (13 March 2024); https://doi.org/10.1117/12.3003068

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KEYWORDS

Fluorescence imaging

Contrast agents

Dyes

Nanoprobes

Vascular imaging

Fluorescence

Heart

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