CONFERENCE PROCEEDINGS
Advanced Search
Home > Journals > J. Biomed. Opt. > Volume 13 > Issue 2 > Article
Open Access
1 March 2008 Optical clearing of human skin: comparative study of permeability and dehydration of intact and photothermally perforated skin
Elina A. Genina, Alexey N. Bashkatov, Anastasiya A. Korobko, Elena A. Zubkova, Valery Viktorovich Tuchin, Ilya V. Yaroslavsky, Gregory B. Altshuler
Author Affiliations +
Journal of Biomedical Optics, Vol. 13, Issue 2, 021102 (March 2008). https://doi.org/10.1117/1.2899149
Abstract
Accelerated diffusion of water and hyperosmotic optical clearing agents is studied as a result of enhanced epidermal permeability. A lattice of microzones (islets) of damage in stratum corneum is induced using a flash-lamp appliqué system. An optical clearing agent composed of 88% glycerol in aqueous solution is used for all experiments. Research of skin dehydration and glycerol delivery through epidermis at both intact and perforated stratum corneum is presented. The dehydration process induced by both stimuli of evaporation and osmotic agent action is studied by weight measurements. Dynamics of refractive index alteration of both glycerol solution and water during their interaction with skin samples is monitored. The amounts of water escaping from skin through the stratum corneum, due to hyperosmotic-agent action, and glycerol penetrating through the skin sample, are estimated. The results show that the proposed method allows for effective transepidermal water loss and delivery of optical clearing agents.
©(2008) Society of Photo-Optical Instrumentation Engineers (SPIE)
Citation Download Citation
Elina A. Genina, Alexey N. Bashkatov, Anastasiya A. Korobko, Elena A. Zubkova, Valery Viktorovich Tuchin, Ilya V. Yaroslavsky, and Gregory B. Altshuler "Optical clearing of human skin: comparative study of permeability and dehydration of intact and photothermally perforated skin," Journal of Biomedical Optics 13(2), 021102 (1 March 2008). https://doi.org/10.1117/1.2899149
Published: 1 March 2008
JOURNAL ARTICLE
 8 PAGES
DOWNLOAD PAPER SAVE TO MY LIBRARY
GET CITATION
Lens.org Logo
CITATIONS
Cited by 72 scholarly publications.
Advertisement
Advertisement
RIGHTS & PERMISSIONS
Get copyright permission  Get copyright permission on Copyright Marketplace
KEYWORDS
Skin
Water
Refractive index
Tissues
Optical clearing
Tissue optics
Diffusion
RELATED CONTENT
Subscribe to Digital Library
Receive Erratum Email Alert
Back to Top