Curved array photoacoustic tomographic system for small animal imaging

John Kenneth Gamelin; Andres Aquirre; Anastasios Maurudis; Fei Huang; Diego Castillo; Lihong V. Wang; Quing Zhu

doi:10.1117/1.2907157

1 March 2008 Curved array photoacoustic tomographic system for small animal imaging

John Kenneth Gamelin, Andres Aquirre, Anastasios Maurudis, Fei Huang, Diego Castillo, Lihong V. Wang, Quing Zhu

Author Affiliations +

Journal of Biomedical Optics, Vol. 13, Issue 2, 024007 (March 2008). https://doi.org/10.1117/1.2907157

Abstract

We present systematic characterization of a photoacoustic imaging system optimized for rapid, high-resolution tomographic imaging of small animals. The system is based on a 128-element ultrasonic transducer array with a 5-MHz center frequency and 80% bandwidth shaped to a quarter circle of 25 mm radius. A 16-channel data-acquisition module and dedicated channel detection electronics enable capture of a 90-deg field-of-view image in less than 1 s and a complete 360-deg scan using sample rotation within 15 s. Measurements on cylindrical phantom targets demonstrate a resolution of better than 200 μm and high-sensitivity detection of 580-μm blood tubing to depths greater than 3 cm in a turbid medium with reduced scattering coefficient μ_s^′=7.8 cm^-1. The system is used to systematically investigate the effects of target size, orientation, and geometry on tomographic imaging. As a demonstration of these effects and the system imaging capabilities, we present tomographic photoacoustic images of the brain vasculature of an exvivo mouse with varying measurement aperture. For the first time, according to our knowledge, resolution of sub-200-μm vessels with an overlying turbid medium of greater than 2 cm depth is demonstrated using only intrinsic biological contrast.

©(2008) Society of Photo-Optical Instrumentation Engineers (SPIE)

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John Kenneth Gamelin, Andres Aquirre, Anastasios Maurudis, Fei Huang, Diego Castillo, Lihong V. Wang, and Quing Zhu "Curved array photoacoustic tomographic system for small animal imaging," Journal of Biomedical Optics 13(2), 024007 (1 March 2008). https://doi.org/10.1117/1.2907157

Published: 1 March 2008

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KEYWORDS

Transducers

Imaging systems

Photoacoustic spectroscopy

Absorption

Tomography

Solids

Brain

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