Bessel-beam Grueneisen relaxation photoacoustic microscopy with extended depth of field

Junhui Shi; Lidai Wang; Cedric Noordam; Lihong V. Wang

doi:10.1117/1.JBO.20.11.116002

2 November 2015 Bessel-beam Grueneisen relaxation photoacoustic microscopy with extended depth of field

Junhui Shi, Lidai Wang, Cedric Noordam, Lihong V. Wang

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Journal of Biomedical Optics, Vol. 20, Issue 11, 116002 (November 2015). https://doi.org/10.1117/1.JBO.20.11.116002

Abstract

The short focal depth of a Gaussian beam limits the volumetric imaging speed of optical resolution photoacoustic microscopy (OR-PAM). A Bessel beam, which is diffraction free, provides a long focal depth, but its side lobes deteriorate image quality when the Bessel beam is directly employed to excite photoacoustic (PA) signals in OR-PAM. We present a nonlinear approach based on the Grueneisen relaxation effect to suppress the side-lobe artifacts in PA imaging. This method extends the focal depth of OR-PAM and speeds up volumetric imaging. We experimentally demonstrated a 1-mm focal depth with a 7-μm lateral resolution and volumetrically imaged a carbon fiber and red blood cell samples.

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Junhui Shi, Lidai Wang, Cedric Noordam, and Lihong V. Wang "Bessel-beam Grueneisen relaxation photoacoustic microscopy with extended depth of field," Journal of Biomedical Optics 20(11), 116002 (2 November 2015). https://doi.org/10.1117/1.JBO.20.11.116002

Published: 2 November 2015

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