Comparative study of shear wave-based elastography techniques in optical coherence tomography

Fernando Zvietcovich; Jannick P. Rolland; Jianing Yao; Panomsak Meemon; Kevin J. Parker

doi:10.1117/1.JBO.22.3.035010

30 March 2017 Comparative study of shear wave-based elastography techniques in optical coherence tomography

Fernando Zvietcovich, Jannick P. Rolland, Jianing Yao, Panomsak Meemon, Kevin J. Parker

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Journal of Biomedical Optics, Vol. 22, Issue 3, 035010 (March 2017). https://doi.org/10.1117/1.JBO.22.3.035010

Abstract

We compare five optical coherence elastography techniques able to estimate the shear speed of waves generated by one and two sources of excitation. The first two techniques make use of one piezoelectric actuator in order to produce a continuous shear wave propagation or a tone-burst propagation (TBP) of 400 Hz over a gelatin tissue-mimicking phantom. The remaining techniques utilize a second actuator located on the opposite side of the region of interest in order to create three types of interference patterns: crawling waves, swept crawling waves, and standing waves, depending on the selection of the frequency difference between the two actuators. We evaluated accuracy, contrast to noise ratio, resolution, and acquisition time for each technique during experiments. Numerical simulations were also performed in order to support the experimental findings. Results suggest that in the presence of strong internal reflections, single source methods are more accurate and less variable when compared to the two-actuator methods. In particular, TBP reports the best performance with an accuracy error <4.1%. Finally, the TBP was tested in a fresh chicken tibialis anterior muscle with a localized thermally ablated lesion in order to evaluate its performance in biological tissue.

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Fernando Zvietcovich, Jannick P. Rolland, Jianing Yao, Panomsak Meemon, and Kevin J. Parker "Comparative study of shear wave-based elastography techniques in optical coherence tomography," Journal of Biomedical Optics 22(3), 035010 (30 March 2017). https://doi.org/10.1117/1.JBO.22.3.035010

Received: 18 November 2016; Accepted: 15 March 2017; Published: 30 March 2017

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