Use of a single xenon flash lamp for photoacoustic computed tomography of multiple-centimeter-thick biological tissue ex vivo and a whole mouse body in vivo

Terence T.  W. Wong; Yong Zhou; Alejandro Garcia-Uribe; Lei Li; Konstantin Maslov; Li Lin; Lihong V. Wang

doi:10.1117/1.JBO.22.4.041003

24 October 2016 Use of a single xenon flash lamp for photoacoustic computed tomography of multiple-centimeter-thick biological tissue ex vivo and a whole mouse body in vivo

Terence T. W. Wong, Yong Zhou, Alejandro Garcia-Uribe, Lei Li, Konstantin Maslov, Li Lin, Lihong V. Wang

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Journal of Biomedical Optics, Vol. 22, Issue 4, 041003 (October 2016). https://doi.org/10.1117/1.JBO.22.4.041003

Abstract

While lasers have been commonly used as illumination sources in photoacoustic (PA) imaging, their high purchase and maintenance costs, as well as their bulkiness, have hindered the rapid clinical dissemination of PA imaging. With this in mind, we explore an alternative illumination source for PA tomography—a xenon flash lamp with high pulse energy and a microsecond pulse width. We demonstrate that, by using a single xenon flash lamp, we can image both a black latex cord placed in chicken breast tissue at a depth of up to 3.5 cm ex vivo and an entire mouse body in vivo. Our findings indicate that the xenon flash lamp, producing optical illumination that is safe for humans, can be potentially applied to human tissue imaging.

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Terence T. W. Wong, Yong Zhou, Alejandro Garcia-Uribe, Lei Li, Konstantin Maslov, Li Lin, and Lihong V. Wang "Use of a single xenon flash lamp for photoacoustic computed tomography of multiple-centimeter-thick biological tissue ex vivo and a whole mouse body in vivo," Journal of Biomedical Optics 22(4), 041003 (24 October 2016). https://doi.org/10.1117/1.JBO.22.4.041003

Published: 24 October 2016

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