This study demonstrates the possibility of the surface enhanced Raman spectroscopy (SERS) method to determine concentrations of methotrexate (MTX) in human plasma. This method makes it possible to detect low concentrations of methotrexate in biological samples with relatively inexpensive portable equipment. The SERS signal may be greatly enhanced using nanostructured plasmonic materials which will make this method highly sensitive, selective and productive. The use of SERS to perform a therapeutic drug monitoring procedure is a promising method because of its extreme sensitivity, specificity and speed of analysis.
Thrombus formation issues play an important role in the occurrence, diagnosis and treatment of cardiovascular diseases. The inhibition of platelet aggregation is currently the main therapeutic approach in treatment and prevention of cardiovascular diseases. Understanding the platelet structure and its spectral response to the antiplatelet therapy is the key to personalized medicine today. According to the World Health Organization (WHO) reports, cardiovascular deceases have been remaining the leading cause of death at the global level for the last two decades. The number of deaths has been increased up to nearly 9 million in 2019 [1]. The COVID-19 pandemic has resulted in cardiovascular decease (CVD) increase, which caused deaths in many countries [2-3]. The paper presents studies of the fluorescence intensity of aromatic amino acids namely tyrosine (Tyr) and tryptophan (Trp) in the presence of spherical rhodium and platinum nanoparticles (Rh and Pt NPs).
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