Dr. Charles P. Maphanga
at CSIR National Laser Ctr
SPIE Involvement:
Author
Area of Expertise:
Human Immunideficiecy Virus (HIV) , Femtosecond laser , Optical drug translocation , Microfluidics , Optical trapping and sorting , Point-of-Care (POC) diagnostic devices
Websites:
Profile Summary

My masters research topic primarily focused on the use of laser technology as an alternative technique for administering drugs (medicines) into the human body in a targeted manner other than using the conventional enteral and parenteral routes of drug administration. I used a pulsed femtosecond laser with high peak power and ultra-short pulses to create a sub-microscopic pore on the cell membrane of HIV-l infected cells (in-vitro) in the presence of antiretroviral (ARV) drugs, and further performed cell viability, cytotoxicity, and HIV-1 infection levels post laser-enhanced drug delivery using molecular biology assays. Currently I am still in the early stages of my PhD degree. In this new exciting adventure I am using microfluidics approach integrated to a laser device in order to design and fabricate a laser-based Point-of-Care (POC) device for real-time HIV qualitative and quantitative testing. This device will be very beneficial especially in resource-limited settings and developing countries.
Publications (15)

Proceedings Article | 13 March 2024 Presentation + Paper
Masixole Yvonne Lugongolo, Saturnin Ombinda-Lemboumba, Charles Maphanga, Phumulani Michael Mcoyi, Ahmed El-Hussein, Patience Mthunzi-Kufa
Proceedings Volume 12860, 1286002 (2024) https://doi.org/10.1117/12.3002395
KEYWORDS: Photonic crystals, Antibodies, Biosensors, Spectroscopy, Biological samples, Biological research, Scanning electron microscopy, Nanoparticles, Gold nanoparticles

Proceedings Article | 16 March 2023 Poster + Paper
Proceedings Volume 12387, 123870K (2023) https://doi.org/10.1117/12.2650057
KEYWORDS: Biosensing, Antibodies, Biosensors, Photonic crystals, Signal detection, Refractive index, Biological research, Atomic force microscopy, Biomolecules, Statistical analysis

Proceedings Article | 16 March 2023 Presentation + Paper
Proceedings Volume 12387, 123870E (2023) https://doi.org/10.1117/12.2650013
KEYWORDS: Antibodies, Biosensing, Gold, Biosensors, Scanning electron microscopy, Biological research, Spectroscopy, Signal detection, Thin films, Statistical analysis

Proceedings Article | 7 March 2023 Presentation + Paper
Masixole Lugongolo, Saturnin Ombinda-Lemboumba, Charles Maphanga, Patience Mthunzi-Kufa
Proceedings Volume 12377, 1237702 (2023) https://doi.org/10.1117/12.2647726
KEYWORDS: Photonic crystals, Antibodies, Gold nanoparticles, Biosensors, UV-Vis spectroscopy, Scanning electron microscopy, Point-of-care devices, Diagnostics, Crystals, Spectroscopy

Proceedings Article | 5 March 2021 Poster + Presentation + Paper
Proceedings Volume 11651, 116510X (2021) https://doi.org/10.1117/12.2578789
KEYWORDS: Nanoparticles, Gold, Transmission electron microscopy, Diagnostics, Adsorption, Surface plasmons, Dielectrics, Biosensors, Biosensing, Biological research

Showing 5 of 15 publications
SIGN IN TO:
  • View contact details

UPDATE YOUR PROFILE
Is this your profile? Update it now.
Don’t have a profile and want one?

Advertisement
Advertisement
Back to Top