Cystic fibrosis (CF) is a condition arising from a genetic disorder of the cystic fibrosis transmembrane conductance regulator (CFTR) protein traversing luminal organ epithelial lining. Nasal potential difference (NPD) measurement can be used to study CF through evaluation of CFTR channel activity. Salt-bridge-based probes in combination with calomel electrodes have been used to provide discriminative information between normal and CF patients. This setup is bulky and less convenient for use in a clinical setting. Thus, we have developed a small caliber NPD probe and validated it in 3 normal subjects, providing results consisted to those reported in literature.
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