This study delves into the largely uncharted domain of biases in photoacoustic imaging, spotlighting potential shortcut learning as a key issue in reliable machine learning. Our focus is on hardware variation biases. We identify device-specific traits that create detectable fingerprints in photoacoustic images, demonstrate machine learning's capability to use these discrepancies to determine the device that acquired the image, and highlight their potential impact on machine learning model predictions in downstream tasks, such as disease classification.
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