Multispectral optoacoustic tomography (MSOT) provides anatomical and functional imaging of tissues without the need for reporter molecules or transfection. We examined the acute vascular disrupting activity of a new microtubule disrupting agent (OXi8007) using MSOT on syngeneic mouse RENCA-luc, and human XP258 orthotopic kidney tumors. In both tumor types, an oxygen gas breathing challenge showed reduced tumor oxygenation and response within 4h of treatment. In RENCA-luc tumors this matched vascular shutdown assessed by dynamic BLI. MSOT additionally confirmed that VDA did not significantly affect the contralateral normal kidney or spine.
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