Prof. Laila M. Montaser Profile

Prof. Laila M. Montaser

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Proceedings Article | 21 August 2020 Presentation + Paper

Innovative patterning of electrospinning fabrication nano scaffolds with cell culturing for liver tissue engineering

Laila Montaser, Sherin Fawzy

Proceedings Volume 11467, 114671I (2020) https://doi.org/10.1117/12.2569180

KEYWORDS: Liver, Tissue engineering, Stem cells, Tissues, Regenerative medicine, Nanolithography, Fabrication, Bone, Scanning electron microscopy, Animal model studies

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Failure of human body organs is believed to be one of the most important health problems all over the world. The application of stem cells in human regenerative medicine could be an alternative to organ transplantation, avoiding the problem of donor shortage and rejection. As few of the current treatment methods result in successful repair of damaged liver, the development of new procedures are warranted. The most recent type of liver regeneration approach is cell based therapy. The application of stem cell technology is gaining interest to be used for hepatic tissue engineering since stem cells have high proliferative capacity and multi-lineage differentiation potential. Stem cell-based therapy has received attention as a possible alternative to organ transplantation, owing to the ability of stem cells to repopulate and differentiate at the engrafted site. Advancements in the fields of stem cell biology and biomaterials science and engineering had been combined to produce strategies by which stem cell attachment; proliferation and differentiation in vitro were supported and enhanced. Before transplantation, cells were generally seeded on innovative modality of Nano scaffolds fabricated by electrospinning technique that recapitulate the extracellular matrix and provide cells with information that is important for tissue development. In this paper, we offer our view on the applying nanotechnology and present current and emergent approach in the field of hepatic tissue engineering for specific application. The application of nanotechnology to stem cell biology would be able to address the challenges of the failure of injected cells to engraft to target tissues.

Proceedings Article | 27 September 2016 Presentation + Paper

Articular cartilage tissue engineering with plasma-rich in growth factors and stem cells with nano scaffolds

Laila Montaser, Hadeer Abbassy, Sherin Fawzy

Proceedings Volume 9930, 99300V (2016) https://doi.org/10.1117/12.2237874

KEYWORDS: Cartilage, Tissue engineering, Stem cells, Tissues, Injuries, Medicine, Bone, Blood, Collagen, In vitro testing

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The ability to heal soft tissue injuries and regenerate cartilage is the Holy Grail of musculoskeletal medicine. Articular cartilage repair and regeneration is considered to be largely intractable due to the poor regenerative properties of this tissue. Due to their low self-repair ability, cartilage defects that result from joint injury, aging, or osteoarthritis, are the most often irreversible and are a major cause of joint pain and chronic disability. However, current methods do not perfectly restore hyaline cartilage and may lead to the apparition of fibro- or continue hypertrophic cartilage. The lack of efficient modalities of treatment has prompted research into tissue engineering combining stem cells, scaffold materials and environmental factors. The field of articular cartilage tissue engineering, which aims to repair, regenerate, and/or improve injured or diseased cartilage functionality, has evoked intense interest and holds great potential for improving cartilage therapy. Plasma-rich in growth factors (PRGF) and/or stem cells may be effective for tissue repair as well as cartilage regenerative processes. There is a great promise to advance current cartilage therapies toward achieving a consistently successful approach for addressing cartilage afflictions. Tissue engineering may be the best way to reach this objective via the use of stem cells, novel biologically inspired scaffolds and, emerging nanotechnology. In this paper, current and emergent approach in the field of cartilage tissue engineering is presented for specific application. In the next years, the development of new strategies using stem cells, in scaffolds, with supplementation of culture medium could improve the quality of new formed cartilage.

Proceedings Article | 21 August 2015 Paper

Nano scaffolds and stem cell therapy in liver tissue engineering

Laila Montaser, Sherin Fawzy

Proceedings Volume 9550, 95500M (2015) https://doi.org/10.1117/12.2188342

KEYWORDS: Stem cells, Tissue engineering, Tissues, Liver, Regenerative medicine, Nanotechnology, Transplantation, In vitro testing, Bone, Nanofibers

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Tissue engineering and regenerative medicine have been constantly developing of late due to the major progress in cell and organ transplantation, as well as advances in materials science and engineering. Although stem cells hold great potential for the treatment of many injuries and degenerative diseases, several obstacles must be overcome before their therapeutic application can be realized. These include the development of advanced techniques to understand and control functions of micro environmental signals and novel methods to track and guide transplanted stem cells. A major complication encountered with stem cell therapies has been the failure of injected cells to engraft to target tissues. The application of nanotechnology to stem cell biology would be able to address those challenges. Combinations of stem cell therapy and nanotechnology in tissue engineering and regenerative medicine have achieved significant advances. These combinations allow nanotechnology to engineer scaffolds with various features to control stem cell fate decisions. Fabrication of Nano fiber cell scaffolds onto which stem cells can adhere and spread, forming a niche-like microenvironment which can guide stem cells to proceed to heal damaged tissues. In this paper, current and emergent approach based on stem cells in the field of liver tissue engineering is presented for specific application. The combination of stem cells and tissue engineering opens new perspectives in tissue regeneration for stem cell therapy because of the potential to control stem cell behavior with the physical and chemical characteristics of the engineered scaffold environment.

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