Prof. Liyong Ma Profile

Prof. Liyong Ma

at Harbin Institute of Technology

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Publications (2)

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Proceedings Article | 28 February 2021 Paper

Intelligent photothermal treatment method based on photoacoustic and photothermal probe assistance

Yiming Ma, Liyong Ma, Yuanyuan Gao, Mingjian Sun

Proceedings Volume 11781, 1178121 (2021) https://doi.org/10.1117/12.2591313

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As a non-invasive, targeted and non-radioactive technology applied to tumor treatment, photothermal therapy is increasingly used in the clinical treatment of tumors due to its high cure rate and few side effects. In order to obtain a better photothermal treatment effect in the actual treatment process, the temperature distribution of the tissue to be treated must be monitored and controlled to prevent unnecessary tissue damage caused by the treatment. Therefore, the photothermal probe and precise control of the treatment temperature become the key to solving the problem. In this paper, a nanoprobe with strong photoacoustic and photothermal properties in one area of near-infrared is designed. At the same time, a photothermal treatment system is designed and combined with nanoprobe for research. This study designed human tissue simulation experiments and found that compared to the case without probe assistance, the photothermal therapy system based on photoacoustic and photothermal probe assistance can achieve temperature control with a temperature error of 1°C , and the temperature control adjustment time has been shortened by 40%, and the overtreatment injury has also been effectively suppressed. More importantly, it is possible to greatly reduce the complexity of the photothermal treatment process in practical applications without the artificial control of continuous laser power. The experimental result shows that the intelligent photothermal treatment method based on the photoacoustic and photothermal nanoprobe is a feasible candidate for tumor treatment and has a good application prospect in the field of tumor treatment.

Proceedings Article | 10 October 2020 Poster + Presentation + Paper

Photothermal therapy method based on photoacoustic/ultrasonic dual-mode temperature measurement and regulation

Yiming Ma, Liyong Ma, Cheng Ma, Yawei Qu, Yuanyuan Gao, Mingjian Sun

Proceedings Volume 11553, 1155322 (2020) https://doi.org/10.1117/12.2573886

KEYWORDS: Tumors, Photoacoustic spectroscopy, Ultrasonics, Tissues, Detection and tracking algorithms, Proteins, Tolerancing, Inflammation, Error analysis, Error control coding

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Tumor photothermal therapy technology has received a lot of attention in recent years due to its non-invasive and targeted properties. However, how to ensure the safety and effectiveness of the photothermal treatment process poses new challenges to researchers. The field of photothermal therapy urgently needs a non-contact and accurate temperature detection method. In this paper, we have proposed a precise temperature detection technology based on photoacoustic and ultrasonic dual mode which can provide accurate and non-contact temperature measurement, and the temperature information of the light-induced ultrasound signals was fused and applied to temperature detection. To validate our method, temperatures of phantom was measured within the temperature range that simulates the heating process of photothermal therapy, and the calculated temperature measurement error was finally within 1 °C. In particular, it was also verified that the measurement accuracy of this method is 30% higher than that of single photoacoustic temperature detection. The results suggested that our method can be potentially used for temperature monitoring during photothermal therapy.

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