In children with sickle cell disease, there is a clinical need for non-invasive quantification of the degree of hemometabolic stress in these patients to mitigate risk of stroke. Frequency-domain near-infrared spectroscopy (FDNIRS) and diffuse correlation spectroscopy (DCS) measures of regional oxygen extraction fraction, cerebral blood flow, and cerebral metabolic rate of oxygen have potential to provide markers of cerebral metabolic stress. In this study, we characterize the intra-subject and inter-operator repeatability of these measures, and we correlate DCS measures of cerebral blood flow index against both arterial spin-labeled MRI and transcranial Doppler ultrasound in a cohort of pediatric SCD patients.
Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks.
You are receiving this notice because your organization may not have SPIE eBooks access.*
*Shibboleth/Open Athens users─please
sign in
to access your institution's subscriptions.
To obtain this item, you may purchase the complete book in print or electronic format on
SPIE.org.
INSTITUTIONAL Select your institution to access the SPIE Digital Library.
PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.