Dr. Mircea Cotlet Profile

Dr. Mircea Cotlet

Senior Scientist at Brookhaven National Lab

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Author

Publications (16)

Proceedings Article | 9 March 2024 Presentation

Enhanced room temperature valley polarization via spin selective charge transfer

Mircea Cotlet

Proceedings Volume PC12884, PC1288403 (2024) https://doi.org/10.1117/12.3003415

KEYWORDS: Polarization, Perovskite, Monolayers, Molybdenum, Quantum spin, Polarized light, Quantum information, Tunable filters, Transition metals, Quantum technology applications

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Proceedings Article | 5 October 2023 Presentation

Valley polarization in transition metal dichalcogenide via spin filtering

Shreetu Shrestha, Mingxing Li, Mircea Cotlet

Proceedings Volume PC12651, PC126510H (2023) https://doi.org/10.1117/12.2679909

KEYWORDS: Polarization, Transition metals, Quantum spin, Tunable filters, Heterojunctions, Quantum information, Ultrafast laser spectroscopy, Quantum information applications, Quantum encoding, Quantum data

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Proceedings Article | 17 March 2023 Presentation

Room temperature valley polarization in transition metal dichalcogenide/chiral perovskite heterostructures

Shreetu Shrestha, Mingxing Li, Mircea Cotlet

Proceedings Volume PC12423, (2023) https://doi.org/10.1117/12.2650947

KEYWORDS: Heterojunctions, Polarization, Perovskite, Transition metals, Cryogenics, Temperature metrology, Spectroscopes, Quantum information, Quantum computing, Quantum communications

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Proceedings Article | 15 March 2023 Presentation

Charge carrier transport in mixed dimensional quantum dot/monolayer transition metal dichalcogenide heterostructures

Mingxing Li, Sidney Bolden, Mircea Cotlet

Proceedings Volume PC12419, (2023) https://doi.org/10.1117/12.2650822

KEYWORDS: Heterojunctions, Transition metals, Lead, Interfaces, Ultrafast phenomena, Microscopy, Confocal microscopy, Absorption, Visible radiation, Quantum dots

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Proceedings Article | 13 February 2020 Paper

Efficient light harvesting biotic-abiotic nanohybrid system incorporating atomically thin van Der Waals transition metal dichalcogenides

Mingxing Li, Jia-Shiang Chen, Mircea Cotlet

Proceedings Volume 11246, 112460A (2020) https://doi.org/10.1117/12.2545059

KEYWORDS: Fluorescence resonance energy transfer, Proteins, Light harvesting, Energy transfer, Molybdenum, Chromophores, Quantum dots, Luminescence, Transition metals, Semiconductors

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Proceedings Article | 8 May 2017 Paper

Time stamping of single optical photons with 10 ns resolution

Irakli Chakaberia, Mircea Cotlet, Merlin Fisher-Levine, Diedra Hodges, Jayke Nguyen, Andrei Nomerotski

Proceedings Volume 10212, 102120Q (2017) https://doi.org/10.1117/12.2262212

KEYWORDS: Photons, Singular optics, Single photon, Optical imaging, Image intensifiers, Sensors, Photon counting, Quantum efficiency, Cameras, Perovskite, Silicon

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Proceedings Article | 9 October 2012 Paper

Large-area Ag nanoparticle arrays for plasmonically enhanced Raman scattering

R. Osgood, P. Stenhouse, C. Quigley, M. Hoey, J. Carlson, K. Lopez, S. Kooi, L. Armstrong, C. Haines, D. Kapoor, M. Cotlet

Proceedings Volume 8457, 845738 (2012) https://doi.org/10.1117/12.930006

KEYWORDS: Silver, Nanoparticles, Surface enhanced Raman spectroscopy, Particles, Raman scattering, Plasmonics, Polymethylmethacrylate, Raman spectroscopy, Data modeling, Absorption

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Proceedings Article | 25 February 2010 Paper

Single molecule fluorescence spectroscopy studies of photo-induced charge transfer between CdSe/ZnS quantum dots and fullerene

Zhihua Xu, Mircea Cotlet

Proceedings Volume 7571, 75710M (2010) https://doi.org/10.1117/12.845922

KEYWORDS: Luminescence, Quantum dots, Fullerenes, Molecules, Positron emission tomography, Fluorescence spectroscopy, Molecular spectroscopy, Glasses, Semiconductors, Solar cells

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Proceedings Article | 16 February 2009 Paper

Intrinsic fluorescent recognition ligand scaffold based on chaperonins and water-soluble semiconductor quantum dots

Hongzhi Xie, Basil Swanson, Hiromi Kawaga, Jonathan Trent, Mudalige Kumara, Thomas Ippolito, Mircea Cotlet

Proceedings Volume 7188, 718807 (2009) https://doi.org/10.1117/12.809576

KEYWORDS: Proteins, Quantum dots, Luminescence, Nanoparticles, Acquisition tracking and pointing, Fluorescence correlation spectroscopy, Diffusion, Semiconductors, Quantum efficiency, Nanostructures

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SPIE Journal Paper | 1 May 2008 Open Access

Probing dimerization and intraprotein fluorescence resonance energy transfer in a far-red fluorescent protein from the sea anemone Heteractis crispa

Guillaume Lessard, Satoshi Habuchi, James Werner, Peter Goodwin, Frans De Schryver, Johan Hofkens, Mircea Cotlet

JBO, Vol. 13, Issue 03, 031212, (May 2008) https://doi.org/10.1117/12.10.1117/1.2937477

KEYWORDS: Chromophores, Luminescence, Green fluorescent protein, Fluorescence resonance energy transfer, Proteins, Fluorescence correlation spectroscopy, Fluorescent proteins, Fluorescence spectroscopy, Molecules, Diffusion

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Proceedings Article | 27 February 2006 Paper

Time-resolved detection of the one- and two-photon excited fluorescence of single molecules of a folding enhanced green fluorescent protein

Mircea Cotlet, Peter Goodwin, Geoffrey Waldo, James Werner

Proceedings Volume 6092, 609204 (2006) https://doi.org/10.1117/12.646697

KEYWORDS: Luminescence, Molecules, Green fluorescent protein, Signal detection, Chromophores, Fluorescence spectroscopy, Proteins, Molecular lasers, Absorption, Rhodamine

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Proceedings Article | 22 February 2006 Paper

Single molecule spectroscopic characterization of a far-red fluorescent protein (HcRed) from the Anthozoa coral Heteractis crispa

Mircea Cotlet, Satoshi Habuchi, Jennifer Whitier, James Werner, Frans De Schryver, Johan Hofkens, Peter Goodwin

Proceedings Volume 6098, 609804 (2006) https://doi.org/10.1117/12.646811

KEYWORDS: Luminescence, Chromophores, Proteins, Molecules, Molecular spectroscopy, Fluorescence spectroscopy, Green fluorescent protein, Absorption, Spectroscopy, Fluorescent proteins

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We report on the photophysical properties of a far-red intrinsic fluorescent protein by means of single molecule and ensemble spectroscopic methods. The green fluorescent protein (GFP) from Aequorea victoria is a popular fluorescent marker with genetically encoded fluorescence and which can be fused to any biological structure without affecting its function. GFP and its variants provide emission colors from blue to yellowish green. Red intrinsic fluorescent proteins from Anthozoa species represent a recent addition to the emission color palette provided by GFPs. Red intrinsic fluorescent markers are on high demand in protein-protein interaction studies based on fluorescence-resonance energy transfer or in multicolor tracking studies or in cellular investigations where autofluorescence possesses a problem. Here we address the photophysical properties of a far-red fluorescent protein (HcRed), a mutant engineered from a chromoprotein cloned from the sea anemone Heteractis crispa, by using a combination of ensemble and single molecule spectroscopic methods. We show evidence for the presence of HcRed protein as an oligomer and for incomplete maturation of its chromophore. Incomplete maturation results in the presence of an immature (yellow) species absorbing/fluorescing at 490/530-nm. This yellow chromophore is involved in a fast resonance-energy transfer with the mature (purple) chromophore. The mature chromophore of HcRed is found to adopt two conformations, a Transoriented form absorbing and 565-nm and non-fluorescent in solution and a Cis-oriented form absorbing at 590-nm and emitting at 645-nm. These two forms co-exist in solution in thermal equilibrium. Excitation-power dependence fluorescence correlation spectroscopy of HcRed shows evidence for singlet-triplet transitions in the microseconds time scale and for cis-trans isomerization occurring in a time scale of tens of microseconds. Single molecule fluorescence data recorded from immobilized HcRed proteins, all point to the presence of two classes of molecules: proteins with Cis and Trans-oriented chromophores. Immobilization of HcRed in water-filled pores of polyvinyl alcohol leads to a polymer matrix - protein barrel interaction which results in a 'freezing' of the chromophore in a stable conformation for which non-radiative deactivation pathways are either suppressed or reduced. As a result, proteins with both Cis- and Trans-oriented chromophores can be detected at the single molecule level. Polymer chain motion is suggested as a mediator for an eventual cis-trans isomerization of the chromophore in the case of single immobilized proteins.

Proceedings Article | 1 July 2004 Paper

Single-molecule spectroscopy to probe competitive fluorescence resonance energy transfer pathways in bichromophoric synthetic systems

Mircea Cotlet, Tom Vosch, Sadahiro Masuo, Marcus Sauer, Klaus Muellen, Johan Hofkens, Frans De Schryver

Proceedings Volume 5322, (2004) https://doi.org/10.1117/12.531322

KEYWORDS: Molecules, Chromophores, Luminescence, Energy transfer, Fluorescence resonance energy transfer, Polymers, Molecular energy transfer, Absorption, Pulsed laser operation, Single molecule spectroscopy

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Proceedings Article | 14 June 2004 Paper

Single molecule surface enhanced resonance Raman scattering (SERRS) of the enhanced green fluorescent protein (EGFP)

Johan Hofkens, Frans De Schryver, Mircea Cotlet, Satoshi Habuchi

Proceedings Volume 5329, (2004) https://doi.org/10.1117/12.531307

KEYWORDS: Molecules, Raman spectroscopy, Proteins, Silver, Luminescence, Chromophores, Resonance enhancement, Particles, Raman scattering, Green fluorescent protein

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Proceedings Article | 14 June 2004 Paper

Spectroscopy and microscopy of the autofluorescent protein DsRed from Discosoma genus coral

Mircea Cotlet, Satoshi Habuchi, Frans De Schryver, Johan Hofkens

Proceedings Volume 5329, (2004) https://doi.org/10.1117/12.531313

KEYWORDS: Chromophores, Luminescence, Molecules, Proteins, Fluorescence spectroscopy, Absorption, Green fluorescent protein, Polarization, Spectroscopy, Fluorescence resonance energy transfer

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Proceedings Article | 19 June 2003 Paper

Excited state processes in individual multichromophoric systems

Johan Hofkens, Tom Vosch, Mircea Cotlet, Satoshi Habuchi, Koen Van Der Biest, Klaus Mullen, Gunter Dirix, Jan Michiels, Jos Vanderleyden, Markus Sauer, Frans De Schryver

Proceedings Volume 4962, (2003) https://doi.org/10.1117/12.488209

KEYWORDS: Chromophores, Luminescence, Dendrimers, Molecules, Photons, Polarization, Polymers, Fluorescent proteins, Absorption, Proteins

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Showing 5 of 16 publications

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