Oyster mushroom has long been consumed for their delicious taste and flavour that they add to our plate. These edible herbs are also rich source of neutraceuticals that impart on it potential free radical scavenging, antioxidant, antiatherogenic, anti-tumor, immunomodulatory and anti-bacterial properties. In the present study, we deciphered the role of mushroom neutraceuticals vis a vis hallmarks of cancer via an in-silico approach. From literature survey, eleven bioactive compounds of Pleurotus ostreatus were identified e.g. Ergosterol, Rutin, β-glucan, Apigenin, Ascorbic acid, Cinnamic acid, Linoleic acid, Niacinnamide, p-coumaric acid, syringic acid and veratric acid. Molecular docking was performed taking these compounds as ligands against epidermal growth factor receptor, caspase 3 and vascular endothelial growth factor proteins, which plays important role in proliferation, apoptosis and angiogenesis of malignant cells. Our finding suggest that Rutin, Ergosterol and β-glucan has shown highest binding affinity against the three proteins and interfere in their functioning inside tumor microenvironment thereby inhibiting process of carcinogenesis and metastasis.
Wild mushroom had sinister reputation because of handful of poisonous species whose accidental ingestion can lead to slow and painful death. However, most of the wild mushrooms are either edible or harmless. Based on ignorance, the common myth and misconceptions about the mushroom were dispelled with understanding in mushroom biology and advent of mushroom biotechnology. Now mushrooms are considered as most delicious food and a potent weapon against malnutrition. Mushroom Biotechnology deals with discovery of new mushrooms, domestication of newly discovered as well as other wild mushrooms, enhancement in the production of fruit bodies, increase in nutritional and medicinal attributes and applications in mitigating the environmental pollution and providing low cost, viable, multipurpose technology to farmers to meet the growing demand of food, feed, fodder, fertilizer and energy. It is an important tool for restoration, replenishment and remediation of earth’s overburdened ecosphere.
We studied the growth and design of solid-solution crystal of mercurous chloride (Hg2Cl2) and mercurous bromide (Hg2Br2). The lattice parameters of the mixtures obey Vagard’s law in the studied composition range. The study demonstrates that properties are very anisotropic with crystal orientation, and performance achievement requires extremely careful fabrication to utilize theoretical AO figure of merit. In addition, some parameters such as crystal growth fabrication, processing time, resolution, field of view and efficiency will be described for imagers based on novel solid solution materials. It was predicted that very similar to the mercurous chloride and mercurous bromide solid solutions also have very large anisotropy, and acousto-optic figure of merit decreases significantly as function of the crystal orientation.
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