Ms. Sarah G. Thappa Profile

Sarah G. Thappa

at Dartmouth College

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Proceedings Article | 26 February 2013 Paper

Development of a biodegradable iron oxide nanoparticle gel for tumor bed therapy

B. Cunkelman, E. Chen, A. Petryk, J. Tate, S. Thappa, R. Collier, P. Hoopes

Proceedings Volume 8584, 858411 (2013) https://doi.org/10.1117/12.2007310

KEYWORDS: Tumors, Cancer, Nanoparticles, Magnetism, Oxides, Oncology, Iron, Tissues, In vivo imaging, Polymer thin films

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Treatments of the post-operative surgical bed have proven appealing as the majority of cancer recurrence following tumor resection occurs at the tumor margin. A novel, biodegradable pullulan-based gel infused with magnetic iron oxide nanoparticles (IONP) is presented here for surgical bed administration followed by hyperthermia therapy via alternating magnetic field (AMF) activation. Pullulan is a water soluble, film-forming starch polymer that degrades at the postoperative wound site to deliver the IONP payload, targeting the remaining cancer cells. Different gel formulations containing various % wt of pullulan were tested for IONP elution. Elution levels and amount of gel degradation were measured by immersing the gel in de-ionized water for one hour then measuring particle concentrations in the supernatant and the mass of the remaining gel formulation. The most promising gel formulations will be tested in a murine model of surgical bed resection to assess in vivo gel dissolution, IONP cell uptake kinetics via histology and TEM analysis, and heating capability of the gel with AMF exposure.

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