Optical coherence tomography (OCT) is non-invasive biomedical imaging technique, which can provide volumetric imaging of the tissue architectural information. In this talk, I will briefly discuss the preliminary results of several ongoing works in my lab, including the quantitative analysis of the microvasculature with the animal model and investigation of the mouse cochlear anatomy.
Oral cancer was ranked as the fifth most common cancers in both sexes in Taiwan in 2014. For patients diagnosed with the advanced or late stage of oral SCC, the five-year survival rate is reported to be ~ 33% suggesting the importance of the early detection of oral cancer. There have been various studies of investigating the clinical utility of OCT for the early detection of oral precancerous lesions with 1300 nm OCT technology. In this study, we have developed a long-wavelength, multiscale OCT imaging system enabling multiscale imaging of the ex vivo oral precancerous tissue with an increased imaging depth. Objectives with two different magnifications are mounted to a power turret, enabling seamless change of the OCT imaging resolution via the software control. OCT imaging over a variety of oral precancer pathologies will be demonstrated with above OCT system.
The inner ear is a small and sophisticated organ, mainly comprising of the vestibular system and cochlea, responsible for hearing function and plays a crucial role in the life wellness.There have been several studies of investigating the cochlear structures with OCT, and most of these studies used OCT systems with a central wavelength of 1.3 µm. However, the utility of 1 µm OCT system for cochlear imaging application has yet been explored albeit the capability of providing OCT images with a higher axial resolution. Therefore, in this study, we have developed a 1.3 µm and a 1 µm OCT system allowing quantitative and spectroscopic comparison of the cochlear microstructures.
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