Objective: The effect of arabinogalactan on immune function in mice has been systematically studied to provide experimental and theoretical basis for clinical and food development and application. Method: Kunming mice were randomly divided into four groups, and a mouse immunosuppressive model was established using cyclophosphamide as a tool drug. Blood routine, immune organs, liver cell physiological sections, and antigen physiological indicators (AST, ALT, MDA, TNF) in the blood were measured- α And IL- β). In vitro lymphocyte proliferation and transformation were also evaluated. Result: We successfully established a cyclophosphamide-induced immunosuppressive mouse model. In the arabinogalactan-treated and the cyclophosphamide-treated groups, increases were observed in body weight, thymus and spleen weight, red blood cells, white blood cells, and lymphocytes. The results of liver tissue sectioning and physiological index analysis showed that the arabinogalactan group could positively regulate various indicators compared to the control group, with significant differences; The positive regulation of arabinogalactan and cyclophosphamide groups was significant compared to the cyclophosphamide group, and the difference was extremely significant; The single use of arabinogalactan has the best effect on various indicators in mice. Conclusion: Arabinogalactan has an antagonistic effect on immunosuppressants, improves various indicators of mouse immune function, and has the effect of enhancing mouse immune function.
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