Mr. Yikun Wang Profile

Yikun Wang

research assistant professor at Hefei Institutes of Physical Science

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Proceedings Article | 5 January 2017 Paper

The research on noninvasive detection of skin cholesterol by diffuse reflectance spectroscopy

Huayi Hou, Yongsheng Han, Meili Dong, Yuanzhi Zhang, Ling Zhu, Yikun Wang, Yong Liu

Proceedings Volume 10245, 102450E (2017) https://doi.org/10.1117/12.2267485

KEYWORDS: Skin, Diffuse reflectance spectroscopy, Tissue optics, Laser tissue interaction, Tissue engineering

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Skin cholesterol is a novel biomarker to assess the risk of atherosclerotic diseases. To detect skin cholesterol noninvasively and rapidly, a system was designed based on the diffuse reflectance spectroscopy. The feasibility of this system was validated through detecting cholesterol of pig skin samples, and skin cholesterol in vivo of subjects. The experimental results showed that, diffuse reflectance absorbance integrated intensity S measured the concentration of cholesterol in the pig skin samples quantitatively. After adjusting for age, gender and other factors, it showed a significant positive correlation between S of subjects and the total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) which were the main risk factors for atherosclerotic diseases with the correlation coefficients 0.860(P <0.01) and 0.787(P <0.01). The study has shown that the diffuse reflectance spectroscopy provides a noninvasive and convenient method for the detection of skin cholesterol, and the noninvasive detection of skin cholesterol in vivo will contribute to the early detection of atherosclerotic diseases.

Proceedings Article | 14 March 2012 Paper

A trifurcated fiber-optic-probe-based optical system designed for AGEs measurement

Yikun Wang, Long Zhang, Ling Zhu, Yong Liu, Gong Zhang, An Wang

Proceedings Volume 8329, 832908 (2012) https://doi.org/10.1117/12.918562

KEYWORDS: Skin, Light sources, Fiber optics, Reflectivity, Luminescence, Tissues, Tissue optics, Charge-coupled devices, Absorption, Optical design

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Advanced Glycation End-products (AGEs) are biochemical end-products of non-enzymatic glycation and are formed irreversibly in human serum and skin tissue. AGEs are thought to play an important role in the pathogenesis of diabetes and corresponding complications. All conventional methods for measuring AGEs must take sampling and measure in vitro. These methods are invasive and have the problem of relatively time-consuming. AGEs have fluorescent characteristics. Skin AGEs can be assessed noninvasively by collecting the fluorescence emitted from skin tissue when excited with proper light. However, skin tissue has absorption and scattering effects on fluorescence of AGEs, it is not reliable to evaluate the accumulation of AGEs according the emitted fluorescence but not considering optical properties of skin tissue. In this study, a portable system for detecting AGEs fluorescence and skin reflectance spectrum simultaneously has been developed. The system mainly consists of an ultraviolet light source, a broadband light source, a trifurcated fiber-optic probe, and a compact charge coupled device (CCD) spectrometer. The fiber-optic probe consists of 36 optical fibers which are connected to the ultraviolet light source, 6 optical fibers connected to the broadband light source, and a core fiber connected to the CCD spectrometer. Demonstrative test measurements with the system on skin tissue of 40 healthy subjects have been performed. Using parameters that are calculated from skin reflectance spectrum, the distortion effects caused by skin absorption and scattering can be eliminated, and the integral intensity of corrected fluorescence has a strong correlation with the accumulation of AGEs. The system looks very promising for both laboratory and clinical applications to monitor AGEs related diseases, especially for chronic diabetes and complications.

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