Dr. Yinlan Ruan Profile

Dr. Yinlan Ruan

Postdoctoral Researcher at Univ of Adelaide

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Publications (7)

Proceedings Article | 30 December 2019 Paper

Ultra-high-resolution fluorescence images in thin phosphor films

N. Riesen, K. Badek, Y. Ruan, T. Monro, H. Riesen

Proceedings Volume 11200, 112000S (2019) https://doi.org/10.1117/12.2541099

KEYWORDS: Luminescence, Samarium, Ultraviolet radiation, Thin films, Image resolution, Optical storage, Imaging systems, Photomasks

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Proceedings Article | 4 March 2019 Presentation

Intracellular delivery of nanoparticles via microelectrophoresis technique (Conference Presentation)

Mengke Han, Sanam Mustafa, Yinlan Ruan, Steven Wiederman, Jiangbo Zhao, Heike Ebendorff-Heidepriem, Joseph Fabian

Proceedings Volume 10893, 108930C (2019) https://doi.org/10.1117/12.2507707

KEYWORDS: Nanoparticles, Quantum dots, Glasses, Medical research, In vivo imaging, In vitro testing, Image sensors, Sensors, Optical sensors, Semiconductors

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Nanoparticles with various properties and functions are of growing interest for biomedical research, such as in vivo and in vitro sensors, imaging agents and delivery vehicles of therapeutics. An effective method to deliver nanoparticles into the intracellular environment is still a major challenge and critical to many biological studies. Current techniques, such as intracellular uptake, electroporation and microinjection, have different benefits and limitations (e.g., aggregation and endosomal degradation of nanoparticles, high cell mortality and low throughput). We demonstrate application of the well-established microelectrophoresis technique for the first time to deliver nanoparticles into target cells using fine-tipped micropipettes, which overcomes some of these delivery difficulties. Semiconductive quantum dots were selected as the nanoparticles in this study as they are widely used for biomedical imaging and sensing due to having functionalized surfaces suitable for bioconjugation, adaptable photophysical properties for multiplexed detection, and superior stability for longer investigation times. We developed a method to prepare monodisperse suspensions of quantum dots with average hydrodynamic diameter of ~20nm, which demonstrated sufficient colloidal stability to prevent aggregation and blockages in the tip of micropipettes during ejection while enabling sufficient electrical conductivity for ejection and recording electrical activity of cells. Fine-tipped glass micropipettes with an average tip inner diameter of 206 nm for ejection but less than 500 nm to minimize the cell membrane damage and cell distortion were successfully fabricated. Finally, quantum dots were successfully delivered into living human embryonic kidney cells using small electrical currents through fine-tipped glass micropipettes. The delivered quantum dots were found to stay monodispersed within the cells for 2 hours. We believe that microelectrophoresis technique may serve as a simple and general strategy for delivering a variety of biocompatible nanoparticles intracellularly in various biological systems.

Proceedings Article | 14 September 2018 Paper

Rewritable multilevel optical data storage in BaFCl nanocrystals

N. Riesen, X. Pan, K. Badek, Y. Ruan, T. Monro, J. Zhao, H. Ebendorff-Heidepriem, H. Riesen

Proceedings Volume 10757, 1075704 (2018) https://doi.org/10.1117/12.2322804

KEYWORDS: Samarium, Luminescence, Nanocrystals, Optical storage, Data storage, Ultraviolet radiation

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Proceedings Article | 23 April 2017 Paper

Fabrication and characterization of an egg-shaped hollow fiber microbubble

Guanjun Wang, Yinlan Ruan, Pinggang Jia, Zhiguo Gui, Pengcheng Zhang, Chao Wang, Shen Liu, Changrui Liao, Guolu Yin, Yiping Wang

Proceedings Volume 10323, 1032322 (2017) https://doi.org/10.1117/12.2262979

KEYWORDS: Glasses, Fabrication, Electrodes, Sensors, Optical fibers, Structured optical fibers, Fiber optics sensors, Single mode fibers, Fabry–Perot interferometers, Gas lasers

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Proceedings Article | 16 May 2008 Paper

Highly efficient fluorescence sensing using microstructured optical fibres: general model and experiment

Shahraam Afshar V., Yinlan Ruan, Stephen Warren-Smith, Heike Ebendorff-Heidepriem, Tanya Monro

Proceedings Volume 7004, 70042Q (2008) https://doi.org/10.1117/12.785997

KEYWORDS: Luminescence, Micro optical fluidics, Glasses, Structured optical fibers, Absorption, Quantum dots, Silica, Bismuth, Optical sensing, Fiber optics sensors

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Proceedings Article | 16 May 2008 Paper

Antibody immobilization within glass microstructured fibers: a route to sensitive and selective biosensors

T. Monro, Y. Ruan, H. Ebendorff-Heidepriem, H. Foo, P. Hoffmann, R. Moore

Proceedings Volume 7004, 70046Q (2008) https://doi.org/10.1117/12.801887

KEYWORDS: Glasses, Optical fibers, Micro optical fluidics, Luminescence, Proteins, Coating, Biosensors, Biosensing, Silica, Structured optical fibers

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Proceedings Article | 3 March 2006 Paper

Photonic integrated circuits in chalcogenide glass for all-optical signal processing

D. Moss, V. Ta'eed, C. Grillet, M. Shokooh-Saremi, L. Fu, M. Rochette, E. Magi, I. C. Littler, B. Eggleton, Y. Ruan, D. Freeman, S. Madden, B. Luther-Davies

Proceedings Volume 6124, 612409 (2006) https://doi.org/10.1117/12.648768

KEYWORDS: Waveguides, Chalcogenide glass, Photonic crystals, Dispersion, Fiber Bragg gratings, Optical filters, All optical signal processing, Nonlinear optics, Ion beams, Nanowires

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Showing 5 of 7 publications

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