Diffusion of Cortexin and Retinalamin in eye sclera

Elina A. Genina; Elena A. Zubkova; Anastasiya A. Korobko; Irina Yu. Yanina; Alexey N. Bashkatov; Tatyana G. Kamenskikh; Vladimir A. Galanzha; Valery V. Tuchin

doi:10.1117/12.741082

26 April 2007 Diffusion of Cortexin and Retinalamin in eye sclera

Elina A. Genina, Elena A. Zubkova, Anastasiya A. Korobko, Irina Yu. Yanina, Alexey N. Bashkatov, Tatyana G. Kamenskikh, Vladimir A. Galanzha, Valery V. Tuchin

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Proceedings Volume 6535, Saratov Fall Meeting 2006: Optical Technologies in Biophysics and Medicine VIII; 65351Y (2007) https://doi.org/10.1117/12.741082
Event: Saratov Fall Meeting 2006, 2006, Saratov, Russian Federation

Abstract

Spectral measurements of sclera reflectance during its interaction with aqueous solutions of both Cortexin and Retinalamin have been carried out. Twenty three samples included in the study were human sclera and rabbit sclera in vitro. The results of the experiments have shown that penetration of Cortexin as well as Retinalamin into sclera tissue leads to the decrease of sclera reflection due to optical immersion. Estimation of diffusion coefficients of studied solutions was made on the basis of analysis of reflectance change dynamics of the sclera samples. Diffusion coefficients of Cortexin and Retinalamin in sclera tissue were estimated as (4.4±2.7)x10^-6 and (1.82±0.14)x10^-6 cm²/sec, respectively. Obtained values of diffusion coefficient allowed estimating time needed for total penetration of both agents through scleral membrane at subtenon's injection of studied agents. The results are important for treatment of partial optic atrophy observed at primary open-angle glaucoma and others eye diseases.

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Elina A. Genina, Elena A. Zubkova, Anastasiya A. Korobko, Irina Yu. Yanina, Alexey N. Bashkatov, Tatyana G. Kamenskikh, Vladimir A. Galanzha, and Valery V. Tuchin "Diffusion of Cortexin and Retinalamin in eye sclera", Proc. SPIE 6535, Saratov Fall Meeting 2006: Optical Technologies in Biophysics and Medicine VIII, 65351Y (26 April 2007); https://doi.org/10.1117/12.741082

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