CONFERENCE PROCEEDINGS
Advanced Search
Home > Journals > J. Biomed. Opt. > Volume 11 > Issue 3 > Article
Open Access
1 May 2006 Temperature distribution in selective laser-tissue interaction
Jared Crochet, Surya C. Gnyawali, Yichao Chen, Evan C. Lemley, Lihong V. Wang, Wei R. Chen
Author Affiliations +
Journal of Biomedical Optics, Vol. 11, Issue 3, 034031 (May 2006). https://doi.org/10.1117/1.2204615
Abstract
Selective photothermal interaction using dye enhancement has proven to be effective in minimizing surrounding tissue damage and delivering energy to target tissue. During laser irradiation, the process of photon absorption and thermal energy diffusion in the target tissue and its surrounding tissue are crucial. Such information allows the selection of proper operating parameters such as dye concentrations, laser power, and exposure time for optimal therapeutic effect. Combining the Monte Carlo method for energy absorption and the finite difference method for heat diffusion, the temperature distributions in target tissue and surrounding tissue in dye enhanced laser photothermal interaction are obtained. Different tissue configurations and dye enhancement are used in the simulation, and different incident beam sizes are also used to determine optimum beam sizes for various tissue configurations. Our results show that the algorithm developed in this study could predict the thermal outcome of laser irradiation. Our simulation indicates that with appropriate absorption enhancement of the target tissue, the temperature in the target tissue and in the surrounding tissue can be effectively controlled. This method can be used for optimization of lesion treatment using laser photothermal interactions. It may also provide guidance for laser immunotherapy in cancer treatment, since the immunological responses are believed to be related to tissue temperature changes.
©(2006) Society of Photo-Optical Instrumentation Engineers (SPIE)
Citation Download Citation
Jared Crochet, Surya C. Gnyawali, Yichao Chen, Evan C. Lemley, Lihong V. Wang, and Wei R. Chen "Temperature distribution in selective laser-tissue interaction," Journal of Biomedical Optics 11(3), 034031 (1 May 2006). https://doi.org/10.1117/1.2204615
Published: 1 May 2006
JOURNAL ARTICLE
 10 PAGES
DOWNLOAD PAPER SAVE TO MY LIBRARY
GET CITATION
Lens.org Logo
CITATIONS
Cited by 59 scholarly publications and 1 patent.
Advertisement
Advertisement
RIGHTS & PERMISSIONS
Get copyright permission  Get copyright permission on Copyright Marketplace
KEYWORDS
Laser tissue interaction
Absorption
Monte Carlo methods
Tissues
Tissue optics
Tumors
Laser irradiation
RELATED CONTENT
Subscribe to Digital Library
Receive Erratum Email Alert
Back to Top