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22 January 2015 In vivo deep brain imaging of rats using oral-cavity illuminated photoacoustic computed tomography
Li Lin, Jun Xia, Terence T. W. Wong, Lei Li, Lihong V. Wang
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Journal of Biomedical Optics, Vol. 20, Issue 1, 016019 (January 2015). https://doi.org/10.1117/1.JBO.20.1.016019
Abstract
Using internal illumination with an optical fiber in the oral cavity, we demonstrate, for the first time, photoacoustic computed tomography (PACT) of the deep brain of rats in vivo. The experiment was performed on a full-ring-array PACT system, with the capability of providing high-speed cross-sectional imaging of the brain. Compared with external illumination through the cranial skull, internal illumination delivers more light to the base of the brain. Consequently, in vivo photoacoustic images clearly reveal deep brain structures such as the hypothalamus, brain stem, and cerebral medulla.
© 2015 Society of Photo-Optical Instrumentation Engineers (SPIE) 0091-3286/2015/$25.00 © 2015 SPIE
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Li Lin, Jun Xia, Terence T. W. Wong, Lei Li, and Lihong V. Wang "In vivo deep brain imaging of rats using oral-cavity illuminated photoacoustic computed tomography," Journal of Biomedical Optics 20(1), 016019 (22 January 2015). https://doi.org/10.1117/1.JBO.20.1.016019
Published: 22 January 2015
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Cited by 48 scholarly publications.
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KEYWORDS
Brain
Neuroimaging
Photoacoustic tomography
Brain imaging
In vivo imaging
Imaging systems
Transducers
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