Optical sensing is a powerful tool for recognition interactions in biosystems. Nowadays sensor systems allow to determinate the biomolecules interactions in biological fluids with high sensitivity, reproducibility and minimum standard error. Usually analyses are carried out in a heterogeneous format, which significantly complicates the procedure and increases the single analysis cost. The swap from heterogeneous to homogeneous analysis format is a promising solution. Microstructured optical fibers (MOFs) are a possible platform for creation of such sensors. Manuscript describe the possibility to detect antigen-antibody interactions in the hollow core microstructured optical fibers (HC MOFs). The determination of such interactions was carried out both in heterogeneous and homogeneous formats. Results demonstrate the prospects of HC MOF as a platform for the detection of antigen-antibody interactions.
One of the most interesting modern platforms for fiber-optic biosensor are microstructured optical fibers. The analytical signal in label-free analysis can be determined by the following mechanisms: changes in the thickness of biomolecule layers immobilized on the surface of the fiber hollow fiber core; small changes in the refractive index of the analyzed solution in the fiber hollow core of the fiber and the absorption spectrum of the analyzed solution. In this article, we report data on the effect of different salt solutions small concentration changes on the MOF HC transmission spectra
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