Mr. Davin J. Miller Profile

Davin J. Miller

SPIE Involvement:

Author

Publications (1)

This will count as one of your downloads.

You will have access to both the presentation and article (if available).

DOWNLOAD NOW

This content is available for download via your institution's subscription. To access this item, please sign in to your personal account.

Email or Username Forgot your username?

Password Forgot your password?

Show

Keep me signed in

No SPIE account? Create an account

Proceedings Article | 15 March 2023 Presentation + Paper

S-cone identification using AO-OCT cone structural measurements and support vector machine classifier

Qiuzhi Ji, Marcel Bernucci, Yan Liu, James Crowell, Davin Miller, Donald Miller

Proceedings Volume 12360, 1236005 (2023) https://doi.org/10.1117/12.2650609

KEYWORDS: Cones, Adaptive optics optical coherence tomography, Reflection, Image segmentation, Reflectivity, Retina, Support vector machines, Eye, Adaptive optics, Video

Read Abstract +

The high resolution of adaptive optics optical coherence tomography (AO-OCT) allows 3-dimensional imaging of individual cone photoreceptors in vivo. Histology has revealed that short-wavelength-sensitive (S) cones have distinct structural features compared with medium-wavelength-sensitive (M) and long-wavelength-sensitive (L) cones. Quantifying these structural features in images of living human retinas may provide a simpler and quicker method for identifying S cones than by imaging cone function (e.g., optoretinography). Here, we present a quantitative method for using AO-OCT measurements of cone structure in a support vector machine (SVM) classifier to identify individual S cones. For every cone cell, we measured six key structural parameters: inner segment length (ISL), outer segment length (OSL), inner segment / outer segment conjunction (IS/OS) diameter, cone outer-segment tip (COST) diameter, IS/OS reflectance, and COST reflectance. ISL and OSL were determined from depth differences between reflections of the external limiting membrane (ELM) and IS/OS, and IS/OS and COST, respectively. Each reflection’s depth was measured with sub-pixel accuracy using Gaussian interpolation; its diameter was measured using the gradient information from the en face projection at that depth. Among 6,398 analyzed cones in six subjects, we found S cones had significantly longer ISLs, shorter OSLs, and wider IS/OS diameters than did cones of other types. We used these structural differences in our SVM model to classify cone spectral types and compared results with cone optoretinography. In five of the six subjects, S cones were identified with F1 scores ranging from 0.78 to 0.93.

My Library

You currently do not have any folders to save your paper to! Create a new folder below.

Folder Name

Folder Description

View contact details

UPDATE YOUR PROFILE

Is this your profile? Update it now.

Sign into your SPIE.org account

Don’t have a profile and want one?

Create an account on SPIE.org

Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks. You are receiving this notice because your organization may not have SPIE eBooks access.*

*Shibboleth/Open Athens users─please sign in to access your institution's subscriptions.

To obtain this item, you may purchase the complete book in print or electronic format on SPIE.org.

ORGANIZATIONAL
Sign in with credentials provided by your organization.

Organizational Username

Organizational Password

Show/Hide Password

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available

Members:

Non-members: ADD TO CART

Keywords/Phrases

Search In:

Publication Years