Dr. Hany Ferdinando Profile

Dr. Hany Ferdinando

at Univ. of Oulu

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Author

Publications (7)

Proceedings Article | 12 March 2024 Presentation + Paper

Validation of Monro-Kellie doctrine during blood pressure lowering in mice using fNIRS

Hany Ferdinando, Jari Jukkola, Sadegh Moradi, Mika Kaakinen, Vesa Kiviniemi, Lauri Eklund, Teemu Myllylä

Proceedings Volume 12841, 1284106 (2024) https://doi.org/10.1117/12.3005682

KEYWORDS: Blood pressure, Blood, Sensors, Water, Brain, Light sources, Ear, Correlation coefficients, Brain tissue, Veins

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Proceedings Article | 12 March 2024 Presentation + Paper

Implementation of a real-time fNIRS signal quality assessment

Hany Ferdinando, Martti Ilvesmäki, Patricia-Elena Tone, Triana Rahayu, Sadegh Moradi, Teemu Myllylä

Proceedings Volume 12841, 1284108 (2024) https://doi.org/10.1117/12.3005688

KEYWORDS: Brain, Wearable devices, Pulse signals, Near infrared spectroscopy

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Proceedings Article | 12 March 2024 Presentation + Paper

Spectral entropy of cerebral fluids during human sleep measured by wearable fNIRS device

Martti Ilvesmäki, Sadegh Moradi, Jari Paunonen, Usko Huuskonen, Mika Kallio, Vesa Kiviniemi, Vesa Korhonen, Elena Krugliakova, Martin Dresler, Hany Ferdinando, Teemu Myllylä

Proceedings Volume 12841, 1284107 (2024) https://doi.org/10.1117/12.3005675

KEYWORDS: Polysomnography, Brain, Fluid dynamics, Tunable filters, Signal filtering, Electronic filtering, Sensors, Mental disorders, Medicine, Medical research

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Proceedings Article | 15 March 2023 Paper

Fractional amplitude of physiological fluctuations of resting state fNIRS in Alzheimer’s disease patient and healthy control

Hany Ferdinando, Sadegh Moradi, Vesa Korhonen, Vesa Kiviniemi, Teemu Myllylä

Proceedings Volume 12365, 1236507 (2023) https://doi.org/10.1117/12.2649864

KEYWORDS: Functional magnetic resonance imaging, Alzheimer disease, Near infrared spectroscopy, Spectral density, Neurological disorders

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Proceedings Article | 7 March 2023 Presentation + Paper

An experimental study of the photoplethysmography waveform analysis on different vessel wall thickness

H. Ferdinando, A. Zienkiewicz, A. Abdelsamie, E. Vihriälä, M. Huotari, T. Myllylä

Proceedings Volume 12378, 123780A (2023) https://doi.org/10.1117/12.2650629

KEYWORDS: Photoplethysmography

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Proceedings Article | 7 March 2023 Presentation + Paper

Dynamics of human cerebral fluids measured by near-infrared spectroscopy

Teemu Myllylä, Martti Ilvesmäki, Sadegh Moradi, Priya Karthikeyan, Vesa Kiviniemi, Hany Ferdinando, Vesa Korhonen

Proceedings Volume 12378, 1237805 (2023) https://doi.org/10.1117/12.2650582

KEYWORDS: Near infrared spectroscopy, Brain, Fluid dynamics, Skull, Magnetic resonance imaging, Water, Skin, Neurodegeneration, Hemodynamics, Anatomy

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SPIE Journal Paper | 31 January 2023 Open Access

Cerebral tissue oxygenation response to brain irradiation measured during clinical radiotherapy

Teemu Myllylä, Vesa Korhonen, Priya Karthikeyan, Ulriika Honka, Jesse Lohela, Kalle Inget, Hany Ferdinando, Sakari Karhula, Juha Nikkinen

JBO, Vol. 28, Issue 01, 015002, (January 2023) https://doi.org/10.1117/12.10.1117/1.JBO.28.1.015002

KEYWORDS: Radiotherapy, Oxygenation, Brain, Tumors, Hemodynamics, Brain tissue, Tissues, Near infrared spectroscopy, Head, Hypoxia

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SignificanceCancer therapy treatments produce extensive changes in the physiological and morphological properties of tissues, which are also individual dependent. Currently, a key challenge involves developing more tailored cancer therapy, and consequently, individual biological response measurement during therapy, such as tumor hypoxia, is of high interest. This is the first time human cerebral haemodynamics and cerebral tissue oxygenation index (TOI) changes were measured during the irradiation in clinical radiotherapy and functional near-infrared spectroscopy (fNIRS) technique was demonstrated as a feasible technique for clinical use in radiotherapy, based on 34 online patient measurements.AimOur aim is to develop predictive biomarkers and noninvasive real-time methods to establish the effect of radiotherapy during treatment as well as to optimize radiotherapy dose planning for individual patients. In particular, fNIRS-based technique could offer an effective and clinically feasible online technique for continuous monitoring of brain tissue hypoxia and responses to chemo- and radiotherapy, which involves modulating tumor oxygenation to increase or decrease tumor hypoxia. We aim to show that fNIRS is feasible for repeatability measuring in patient radiotherapy, the temporal alterations of tissue oxygenation induced by radiation.ApproachFiber optics setup using multiwavelength fNIRS was built and combined with a medical linear accelerator to measure cerebral tissue oxygenation changes during the whole-brain radiotherapy treatment, where the radiation dose is given in whole brain area only preventing dosage to eyes. Correlation of temporal alterations in cerebral haemodynamics and TOI response to brain irradiation was quantified.ResultsOnline fNIRS patient measurement of cerebral haemodynamics during clinical brain radiotherapy is feasible in clinical environment, and results based on 34 patient measurements show strong temporal alterations in cerebral haemodynamics and decrease in TOI during brain irradiation and confirmed the repeatability. Our proof-of-concept study shows evidently that irradiation causes characteristic immediate changes in brain tissue oxygenation.ConclusionsIn particular, TOI seems to be a sensitive parameter to observe the tissue effects of radiotherapy. Monitoring the real-time interactions between the subjected radiation dose and corresponding haemodynamic effects may provide important tool for the researchers and clinicians in the field of radiotherapy. Eventually, presented fNIRS technique could be used for improving dose planning and safety control for individual patients.

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