Dr. Sharon Thomsen Profile

Dr. Sharon Thomsen

Pathology Consultant

SPIE Involvement:

Author | Instructor

Publications (70)

Proceedings Article | 22 February 2017 Paper

Complications of vessel architecture and the the reason that cylindrical electrodes are generally not effective

John Pearce, Sharon Thomsen

Proceedings Volume 10066, 100660S (2017) https://doi.org/10.1117/12.2250397

KEYWORDS: Electrodes, Blood vessels, Arteries, Collagen, Numerical modeling, Tissues, Veins, Thermal modeling, Natural surfaces, Finite element methods, Temperature metrology, Explosives

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Proceedings Article | 11 March 2015 Paper

Practical pathology for thermal tissue applications

Colleen Beatty, Sharon Thomsen, Jeffrey Vos, James Coad

Proceedings Volume 9326, 932602 (2015) https://doi.org/10.1117/12.2082934

KEYWORDS: Tissues, Collagen, Pathology, Arteries, Injuries, Cell death, Microwave radiation, Medical devices, Birefringence, Nerve

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Proceedings Article | 11 March 2015 Paper

Coupling of physical characteristics of non-ionizing irradiation to specific mechanisms of cell death: are we there yet?

Sharon Thomsen

Proceedings Volume 9326, 932603 (2015) https://doi.org/10.1117/12.2080881

KEYWORDS: Proteins, Tissues, Cell death, Cytoskeletons, Receptors, Molecules, Ion channels, Organisms, Macromolecules, Temperature metrology

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SPIE Journal Paper | 23 February 2015 Open Access

Infrared neural stimulation of human spinal nerve roots in vivo

Jonathan Cayce, Jonathon Wells, Jonathan Malphrus, Chris Kao, Sharon Thomsen, Noel Tulipan, Peter Konrad, E. Duco Jansen, Anita Mahadevan-Jansen

NPh, Vol. 2, Issue 01, 015007, (February 2015) https://doi.org/10.1117/12.10.1117/1.NPh.2.1.015007

KEYWORDS: Nerve, Infrared radiation, Tissues, Electromyography, Safety, In vivo imaging, Optical fibers, Surgery, Diagnostics, Tissue optics

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Proceedings Article | 26 February 2013 Paper

Nanoparticles in medicine: selected observations and experimental caveats

Sharon Thomsen, John Pearce, Andrew Giustini, P. Jack Hoopes

Proceedings Volume 8584, 858402 (2013) https://doi.org/10.1117/12.2008900

KEYWORDS: Nanoparticles, Particles, Tissues, Natural surfaces, Proteins, Manufacturing, Blood, Cancer, Molecules, Medicine

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Proceedings Article | 24 February 2011 Open Access

The art and science of low-energy applications in medicine: pathology perspectives

Sharon Thomsen

Proceedings Volume 7901, 790102 (2011) https://doi.org/10.1117/12.877565

KEYWORDS: Cell death, Tissues, Receptors, Ultrasonography, Proteins, Plasma, Cancer, Medicine, Pathology, Diagnostics

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Proceedings Article | 24 February 2009 Paper

Targeted thermal injury: mechanisms of cell and tissue death

Sharon Thomsen

Proceedings Volume 7181, 718102 (2009) https://doi.org/10.1117/12.828621

KEYWORDS: Cell death, Tissues, Proteins, Injuries, Genetics, Plasma, Macromolecules, Molecules, Receptors, Telecommunications

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Proceedings Article | 21 February 2007 Paper

Damage threshold of in-vivo rabbit cornea by 2-um laser irradiation

Bo Chen, Jeffery Oliver, Soumak Dutta, Grady Rylander, Sharon Thomsen, Ashley Welch

Proceedings Volume 6435, 64350B (2007) https://doi.org/10.1117/12.701796

KEYWORDS: Laser damage threshold, Cornea, Safety, Infrared cameras, Laser irradiation, Cameras, Laser safety, Eye, Absorption, Lamps

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To support refinement of the Maximum Permissible Exposure (MPE) safety limits, a series of experiments were conducted in vivo on Dutch Belted rabbit corneas to determine corneal minimum visible lesion thresholds for 2.0 &mgr;m continuous-wave laser irradiation. Single pulse radiant exposures were made at specified pulse durations of 0.1 sec, 0.25 sec, 0.5 sec, 1.0 sec, 2.0 sec and 4.0 seconds for spot 1/e² diameters of 1.17 mm and 4.02 mm. Lesions were placed in rows without overlap on rabbit cornea. The effect of each irradiation was evaluated within one minute post exposure and the final determination of lesion formation was made using a slit lamp one hour post exposure. Threshold lesions were defined as the presence of a superficial surface whitening one hour after irradiation. Probit analysis was conducted to estimate the dose for 50% probability (ED50) of laser-induced damage. Approximately 20 different radiant exposures were made for each exposure duration-spot size combination. At the threshold level, the diameters of barely visible opaque white lesions were smaller than the Gaussian 1/e² beam diameter. In selected survival animals, most of the threshold lesions were still visible 24 hours after exposure. The average lesion radius was approximately 0.4 ± 0.12 mm diameter for the 1.17 mm spot size and 1.0 ± 0.20 mm diameter for the 4.02 mm spot size. The exposure duration dependence of threshold average radiant exposure was described by an empirical power law equation: Threshold radiant exposure[J/cm2] = a x exposure duration[s] ^b, experimentally derived coefficient a was 9.79 and b was 0.669 for the 1.17 mm spot diameter; values of a and b were 4.57 and 0.456 respectively for the 4.02 spot diameter. Based on the experimental data and the empirical power law, the safety factors which were defined as threshold radiant exposure divided by MPE values were predicted for the 2.0 &mgr;m wavelength at various exposure durations and spot diameters. The minimum limit of the safety factor was approximately a factor of four for both 4.02 mm and 1.17 mm spot diameters. Due to the very sharp boundary and small uncertainties of damage threshold determination, it is suggesting that a factor of 4 "padding" is adequate and safety standard may not need to be changed.

Proceedings Article | 9 February 2007 Paper

Developing clinically successful biomedical devices by understanding the pathophysiology of the target tissue: insights from over 25 years at the microscope

Sharon Thomsen, James Coad

Proceedings Volume 6440, 644002 (2007) https://doi.org/10.1117/12.699273

KEYWORDS: Tissues, Injuries, Proteins, Pathology, Wound healing, Tissue optics, Microscopes, Biomedical optics, Ultrasonography, Inflammation

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Volumetric conductive-convective heat sources, microwave and radiofrequency energy sources, high intensity focused ultrasound (HIFU), laser irradiation and other non-ionizing irradiation sources can be used to generate hyperthermic tissue injury in a variety of clinical settings with therapeutic temperature gradients ranging from 40 to over 90°C. On the opposite side, cryotherapy can be used to freeze tissues with negative therapeutic temperature gradients. The development of a successful thermal therapy using any one of these devices requires a precise understanding of the desired clinical end point in terms of 1) diagnosis vs. therapy, 2) cure vs. palliative intent, 3) dysfunctional vs. malignant tissue and 4) long-term monitoring issues. The effects of a specific thermal exposure depend on the architecture of the heat source and overall thermal history. During initial treatment before heat generation or cooling becomes dominant, tissue interactions with the delivered treatment may affect the geometry of the treatment effect and body's healing response. These two parameters are also affected by tissue anatomy, blood supply and protein vs. lipid content. The thermal lesion and final clinical outcome represent the sum of direct primary and secondary short and long term delayed injury. The latter occurs primarily from host responses producing ischemia, inflammation and wound healing followed by possible regeneration and/or scar formation. Once the thermal insult has been deployed, the resulting lesions can be broadly divided into two major zones: 1) a complete tissue ablation with lethal tissue injury closer to the device and 2) a peripheral transition zone of partial injury. Hyperthermic complete ablation zones can have two sub-regions: 1) thermal fixation from direct denaturation of cellular and tissue components and 2) coagulative necrosis due to direct injury and delayed secondary host responses. With a variety of special techniques, direct cellular injury can be studied at post-therapy intervals of less than 12 hours. At 1-5 days, the acute effects of direct and secondary injury can be assessed with hematoxylin and eosin staining and other techniques. While early healing changes can be studied around 7-10 days, chronic changes are best assessed at variable intervals between 1-9 months. A thorough understanding of the interval dynamics of direct and delayed tissue responses after treatment is critical when choosing appropriate post-treatment times to assess the results. Since many preclinical studies represent "snap shots" in time, care needs to be taken when using acute experimental results to develop mathematical models to predict chronic clinical outcomes. Recent collaborative studies indicate that many pathologic effects can act as direct markers of clinical efficacy when combined with various imaging modalities. In addition, both animal and human studies are performed to establish safety and efficacy; therefore, understanding species differences and the appropriate selection of pathology techniques is critical when designing these studies. In summary, effective biomedical instrument development requires close cooperation among engineers, physiologists, internists, pathologists and radiologists from conceptualization through instrument development, validation and refinement.

Proceedings Article | 8 February 2007 Paper

Histological study of skin damage by 2.0um laser irradiation

Bo Chen, Sharon Thomsen, Daniel O’Dell, Robert Thomas, Ashley Welch

Proceedings Volume 6440, 644004 (2007) https://doi.org/10.1117/12.700546

KEYWORDS: Skin, Laser irradiation, Inflammation, Collagen, Laser damage threshold, Birefringence, Blood vessels, Tissues, Injuries, Data modeling

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SPIE Journal Paper | 1 November 2006 Open Access

Modeling thermal damage in skin from 2000-nm laser irradiation

Bo Chen, Sharon Thomsen, Robert Thomas, Ashley Welch

JBO, Vol. 11, Issue 06, 064028, (November 2006) https://doi.org/10.1117/12.10.1117/1.2402114

KEYWORDS: Skin, Laser irradiation, Thermal modeling, Laser damage threshold, Temperature metrology, Standards development, Absorption, Tissue optics, Optical simulations, Tissues

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Proceedings Article | 28 February 2006 Paper

Threshold damage of in vivo porcine skin at 2000 nm laser irradiation

Bo Chen, Daniel O'Dell, Sharon Thomsen, Benjamin Rockwell, Ashley Welch

Proceedings Volume 6084, 60840C (2006) https://doi.org/10.1117/12.639069

KEYWORDS: Skin, Laser damage threshold, Laser irradiation, Infrared cameras, Laser safety, Infrared imaging, Cameras, Injuries, Standards development, In vivo imaging

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Proceedings Article | 14 April 2005 Paper

Nonthermal effects in thermal treatment applications of nonionizing irradiation

Sharon Thomsen

Proceedings Volume 5698, (2005) https://doi.org/10.1117/12.592471

KEYWORDS: Tissues, Thermal effects, Proteins, Blood, Cell death, Microscopy, Wound healing, Tissue optics, Blood vessels, Liver

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Proceedings Article | 1 July 2004 Paper

Spatial refractive index measurement of porcine artery using differential phase OCT

Jeehyun Kim, Digant Dave, Chris Rylander, Marc Feldman, Sharon Thomsen, Thomas Milner

Proceedings Volume 5316, (2004) https://doi.org/10.1117/12.529835

KEYWORDS: Refractive index, Arteries, Optical coherence tomography, Tissues, Polarization, Prisms, Tissue optics, Image processing, Phase modulation, Michelson interferometers

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Proceedings Article | 10 June 2003 Paper

Thermal damage parameters from laser coagulation experiments

John Pearce, Sharon Thomsen

Proceedings Volume 4954, (2003) https://doi.org/10.1117/12.476339

KEYWORDS: Thermal effects, Laser coagulation, Process modeling, Liver, Tissues, Thermal modeling, Proteins, Natural surfaces, In vivo imaging, Calibration

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Proceedings Article | 10 June 2003 Paper

Practical pathology for engineers: how to do the job right the first time

Sharon Thomsen

Proceedings Volume 4954, (2003) https://doi.org/10.1117/12.476635

KEYWORDS: Tissues, Biomedical optics, Diagnostics, Proteins, Arteries, Breast, Blood, Natural surfaces, Transmission electron microscopy, Pathology

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Proceedings Article | 17 June 2002 Paper

In-vivo study of epidermal protection by cryogen spray cooling during pulsed-laser irradiation at high radiant exposures

James Tunnell, David Chang, Carol Johnston, Jorge Torres, Charles Patrick, Michael Miller, Sharon Thomsen, Bahman Anvari

Proceedings Volume 4609, (2002) https://doi.org/10.1117/12.431782

KEYWORDS: Skin, Cryogenics, Tissues, Laser therapeutics, Injuries, In vivo imaging, Pulsed laser operation, Laser damage threshold, Blood vessels, Blood

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Proceedings Article | 24 October 2001 Paper

Optoacoustic images of early cancer in forward and backward modes

Alexander Karabutov, Valeri Andreev, Brent Bell, R. Declan Fleming, Zoran Gatalica, Massoud Motamedi, Elena Savateeva, Harbans Singh, Sergey Solomatin, Sharon Thomsen, P. Henrichs, Alexander Oraevsky

Proceedings Volume 4434, (2001) https://doi.org/10.1117/12.446687

KEYWORDS: Tissues, Transducers, Tumors, Ultrasonics, Breast, Tissue optics, Cancer, Acoustics, Absorption, Natural surfaces

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Proceedings Article | 7 June 2001 Paper

Imaging the primate retina using polarization-sensitve optical coherence tomography

Jason Marsack, Mathieu Ducros, Sapun Parekh, Sharon Thomsen, Henry Rylander, Thomas Milner

Proceedings Volume 4245, (2001) https://doi.org/10.1117/12.429286

KEYWORDS: Retina, Optic nerve, Optical coherence tomography, Polarization, Eye, Birefringence, Tissue optics, Signal detection, Retinal scanning, Nerve

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Proceedings Article | 1 June 2001 Paper

Influence of different anatomies on healing of interstitial thermal lesions in goat and pig breasts

Sharon Thomsen, Thomas Ryan, Lynetta Freeman, Mark DiFrancesco

Proceedings Volume 4247, (2001) https://doi.org/10.1117/12.427870

KEYWORDS: Breast, Tissues, Wound healing, Nipple, Blood vessels, Cancer, Solids, Blood circulation, Physiology, Breast cancer

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Proceedings Article | 17 May 2000 Paper

Use of osmotically active agents to alter optical properties of tissue: influence on the detected fluorescence signal from a subsurface target

Gracie Vargas, Kin Foong Chan, Sharon Thomsen, Ashley Welch

Proceedings Volume 3907, (2000) https://doi.org/10.1117/12.386242

KEYWORDS: Signal detection, Tissue optics, Skin, Luminescence, Scattering, Tissues, In vitro testing, In vivo imaging, Optical properties, Fluorescence spectroscopy

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Proceedings Article | 24 January 2000 Open Access

Therapeutic implications of heat-induced lung injury

Joe Putnam, Sharon Thomsen, Michael Siegenthaler

Proceedings Volume 10297, 1029707 (2000) https://doi.org/10.1117/12.375227

KEYWORDS: Lung, Injuries, Radiofrequency ablation, Thermal modeling, Blood circulation, Tissues, Lung cancer

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Proceedings Article | 24 January 2000 Open Access

Qualitative and quantitative pathology of clinically relevant thermal lesions

Sharon Thomsen

Proceedings Volume 10297, 102970H (2000) https://doi.org/10.1117/12.375218

KEYWORDS: Pathology, Combustion, Metals, Tumors, Electromagnetism, Therapeutics, Laser tissue interaction, Light, Microwave radiation, Ultrasonography

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Proceedings Article | 24 January 2000 Open Access

Blood vessel architectural features and their effects on thermal phenomena

John Pearce, Sharon Thomsen

Proceedings Volume 10297, 1029706 (2000) https://doi.org/10.1117/12.375226

KEYWORDS: Thermal effects, Blood vessels, Tissues, Arteries, Veins, Capillaries

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Proceedings Article | 15 July 1999 Paper

Optoacoustic imaging of oral cancer: feasibility studies in hamster model of squamous cell carcinoma

Alexander Oraevsky, Alexander Karabutov, Elena Savateeva, Brent Bell, Massoud Motamedi, Sharon Thomsen, Pankaj Jay Pasricha

Proceedings Volume 3597, (1999) https://doi.org/10.1117/12.356791

KEYWORDS: Tissues, Cancer, Transducers, Tissue optics, Natural surfaces, Tomography, Laser tissue interaction, Ultrasonics, Acoustics, Tumor growth modeling

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Proceedings Article | 19 May 1999 Paper

Mapping of thermal injury in biologic tissues using quantitative pathologic techniques

Sharon Thomsen

Proceedings Volume 3594, (1999) https://doi.org/10.1117/12.348748

KEYWORDS: Tissues, Proteins, Collagen, Birefringence, Wound healing, Injuries, Cell death, Blood vessels, Natural surfaces, Liver

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Proceedings Article | 19 May 1999 Paper

Real time fiber optic detection of lethal thermal injury in vivo

Sharon Thomsen, Jon Schwartz, Edward Sinofsky

Proceedings Volume 3594, (1999) https://doi.org/10.1117/12.348728

KEYWORDS: Tissues, Liver, Injuries, Fiber optics, In vivo imaging, Natural surfaces, Absorption, Blood, Computed tomography, Cancer

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Proceedings Article | 1 July 1998 Paper

Skin resurfacing using an ultrasonic surgical aspirator

Kate Lawes, Sharon Thomsen, Kathy Nolan, Jan Carr, Jenifer Kennedy

Proceedings Volume 3245, (1998) https://doi.org/10.1117/12.312326

KEYWORDS: Tissues, Skin, Ultrasonics, Birefringence, Inflammation, Collagen, Injuries, Gas lasers, Laser therapeutics, Lithium

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Proceedings Article | 1 July 1998 Paper

Infrared imaging of CO2 laser ablation: implications for laser skin resurfacing

Bernard Choi, Jennifer Barton, Eric Chan, Sharon Thomsen, Ashley Welch

Proceedings Volume 3245, (1998) https://doi.org/10.1117/12.312306

KEYWORDS: Skin, Tissues, Temperature metrology, Carbon dioxide lasers, Laser ablation, Combustion, Natural surfaces, Cameras, In vivo imaging, Laser tissue interaction

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Proceedings Article | 1 July 1998 Paper

Chronology of healing events in pulsed CO2 laser skin resurfacing in fuzzy rat

Sharon Thomsen, Jeff Ellard, Jon Schwartz, Kathy Nolan

Proceedings Volume 3245, (1998) https://doi.org/10.1117/12.312305

KEYWORDS: Skin, Tissues, Collagen, Natural surfaces, Carbon dioxide lasers, Chronology, Wound healing, Inflammation, Pulsed laser operation, Laser applications

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Proceedings Article | 16 April 1998 Paper

Anatomic and physiologic factors influencing transcutaneous optical diagnosis of deep-seated lesions

Sharon Thomsen

Proceedings Volume 3250, (1998) https://doi.org/10.1117/12.305373

KEYWORDS: Skin, Tissue optics, Tissues, Collagen, Scattering, Active optics, Diagnostics, Light scattering, Water, Biopsy

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Proceedings Article | 16 April 1998 Paper

Anisotropic absorption and reduced scattering spectra of chicken breast tissue measured using oblique incidence reflectometry

Lihong Wang, Guillermo Marquez, Sharon Thomsen

Proceedings Volume 3250, (1998) https://doi.org/10.1117/12.305386

KEYWORDS: Scattering, Optical fibers, Absorption, Light scattering, Tissues, Optical properties, Tissue optics, Breast, Reflectometry, Diffuse reflectance spectroscopy

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Proceedings Article | 2 April 1998 Paper

Effect of vessel architecture on fusion by radio frequency current

John Pearce, Sharon Thomsen

Proceedings Volume 3249, (1998) https://doi.org/10.1117/12.304345

KEYWORDS: Tissues, Arteries, Collagen, Electrodes, Thermal modeling, Skin, Natural surfaces, Veins, Animal model studies, Temperature metrology

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Proceedings Article | 2 April 1998 Paper

Quantitative and qualitative histopathological comparisons of multielectrode balloon and thermal balloon endometrial ablation

Sharon Thomsen, Thomas Ryan, Karen Kuk-Nagle, Cindi Soto, Thierry Vancaillie, Jose Garza-Leal

Proceedings Volume 3249, (1998) https://doi.org/10.1117/12.304335

KEYWORDS: Tissues, Uterus, Natural surfaces, Solids, Temperature sensors, Pathology, In vivo imaging, Biopsy, Calibration, Thermal effects

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Proceedings Article | 2 April 1998 Paper

Controlled radio frequency vessel sealing system for surgical applications

Jenifer Kennedy, Steve Buysse, James Chandler, Jeff Eggleston, Kenneth Taylor, Sharon Thomsen

Proceedings Volume 3249, (1998) https://doi.org/10.1117/12.304336

KEYWORDS: Tissues, Ultrasonics, Fusion energy, Collagen, Arteries, Electrodes, Prototyping, Reliability, Amplifiers, Explosives

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Proceedings Article | 18 August 1997 Paper

Laser optoacoustic imaging for breast cancer diagnostics: limit of detection and comparison with x-ray and ultrasound imaging

Rinat Esenaliev, Alexander Karabutov, Frank Tittel, Bruno Fornage, Sharon Thomsen, Carol Stelling, Alexander Oraevsky

Proceedings Volume 2979, (1997) https://doi.org/10.1117/12.280213

KEYWORDS: Tumors, Optical spheres, Tissues, Breast, Acoustics, Absorption, X-ray imaging, X-rays, Ultrasonography, Transducers

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Proceedings Article | 16 June 1997 Paper

Measurement of absorption and scattering spectra of chicken breast with oblique incidence reflectometry

Guillermo Marquez, Lihong Wang, Shao-Pow Lin, Steven Jacques, Frank Tittel, Sharon Thomsen, Jon Schwartz

Proceedings Volume 2976, (1997) https://doi.org/10.1117/12.275539

KEYWORDS: Absorption, Scattering, Optical fibers, Optical properties, Breast, Light scattering, Tissue optics, Diffuse reflectance spectroscopy, Tissues, Reflectometry

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Proceedings Article | 22 May 1997 Paper

Histopathology of laser skin resurfacing

Sharon Thomsen, Bonnie Baldwin, Eric Chi, Jeff Ellard, Jon Schwartz

Proceedings Volume 2970, (1997) https://doi.org/10.1117/12.275056

KEYWORDS: Skin, Collagen, Pulsed laser operation, Tissues, Wound healing, Birefringence, Laser irradiation, Inflammation, Optical testing, Microscopy

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Proceedings Article | 22 May 1997 Paper

Infrared imaging of CO2 laser resurfacing

Ashley Welch, Eric Chan, Jennifer Barton, Bernard Choi, Sharon Thomsen

Proceedings Volume 2970, (1997) https://doi.org/10.1117/12.275061

KEYWORDS: Temperature metrology, Pulsed laser operation, Carbon dioxide lasers, Skin, Cameras, Laser ablation, Tissues, Picosecond phenomena, Infrared imaging, Laser tissue interaction

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Proceedings Article | 2 May 1997 Paper

Institutional safety certification of a research class IV laser for clinical photodynamic therapy

Jon Schwartz, Sharon Thomsen, Erle Janssen, Sharon Erickson, Daniel Supkis, Jr.

Proceedings Volume 2974, (1997) https://doi.org/10.1117/12.275242

KEYWORDS: Laser safety, Photodynamic therapy, Safety, Optical fibers, Control systems, Fiber lasers, Eyewear, Laser therapeutics, Beam controllers, Eye

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Proceedings Article | 6 December 1996 Paper

Detection of cervical precancer using optical spectroscopy (Extended Abstract)

Nirmala Ramanujam, Michele Follen-Mitchell, Anita Mahadevan-Jansen, Constantinos Pitris, Anant Agrawal, Sharon Thomsen, Gregg Staerkel, Thomas Wright, Rebecca Richards-Kortum

Proceedings Volume 2926, (1996) https://doi.org/10.1117/12.260814

KEYWORDS: Algorithm development, Raman spectroscopy, Tissues, Luminescence, Optical spectroscopy, Diagnostics, Fluorescence spectroscopy, Cervix, Target detection, In vivo imaging

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Proceedings Article | 17 May 1996 Paper

Contributions of wound configurations to anastomotic strengths: comparisons of argon and Ho:YAG laser-assisted rat intestine tissue welds

Sharon Thomsen, Inci Cilesiz, Ashley Welch

Proceedings Volume 2671, (1996) https://doi.org/10.1117/12.240017

KEYWORDS: Argon ion lasers, Wound healing, Argon, Intestine, Tissues, Continuous wave operation, Laser stabilization, Natural surfaces, Laser tissue interaction, Ions

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Proceedings Article | 7 May 1996 Paper

Wavelength dependency of soft tissue coagulation with a tunable cw laser

Eric Chan, Behrang Amini, Jennifer Barton, Ashley Welch, Sharon Thomsen, Robert Stoneman, Leon Esterowitz

Proceedings Volume 2681, (1996) https://doi.org/10.1117/12.239561

KEYWORDS: Absorption, Tissues, Laser tissue interaction, Cornea, Cameras, Liver, Continuous wave operation, Breast, Tunable lasers, Temperature metrology

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Proceedings Article | 5 April 1996 Paper

Autofluorescence detection of oxidized LDL in monocytes: a novel risk factor for the assessment of atherosclerosis?

Tami Fink, Alexander Oraevsky, Frank Tittel, Sharon Thomsen, Steven Jacques

Proceedings Volume 2679, (1996) https://doi.org/10.1117/12.237595

KEYWORDS: Luminescence, Foam, Spectroscopy, Quartz, Absorption, Microscopes, Solids, Blood, Objectives, Control systems

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Proceedings Article | 31 January 1996 Paper

Whole bladder wall photodynamic therapy using 5-ALA: an experimental study in pigs

Hugo van Staveren, Johan Beek, Cess Verlaan, Annie Edixhoven, Anne Saarnak, Dick Sterenborg, Theo de Reijke, Guy de la Riviere, Sharon Thomsen, Martin van Gemert, Willem Star

Proceedings Volume 2625, (1996) https://doi.org/10.1117/12.230951

KEYWORDS: Bladder, Photodynamic therapy, Tissue optics, Tissues, Plasma, Biopsy, Stomach, Skin, Light scattering, In vitro testing

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Proceedings Article | 10 January 1996 Paper

Laser Action in dye-infused biological tissue

Lihong Wang, Da Liu, Nancy He, Steven Jacques, Sharon Thomsen

Proceedings Volume 2624, (1996) https://doi.org/10.1117/12.229544

KEYWORDS: Tissues, Laser tissue interaction, Laser scattering, Rhodamine, Bioalcohols, Absorption, Tissue optics, Pulsed laser operation, Scattering, Light scattering

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Proceedings Article | 30 May 1995 Paper

Lateral and z-axial resolution in laser optoacoustic imaging with ultrasonic transducers

Alexander Oraevsky, Rinat Esenaliev, Steven Jacques, Sharon Thomsen, Frank Tittel

Proceedings Volume 2389, (1995) https://doi.org/10.1117/12.209986

KEYWORDS: Tissues, Acoustics, Transducers, Natural surfaces, Signal detection, Diffraction, Absorption, Temporal resolution, Image resolution, Blood vessels

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Proceedings Article | 22 May 1995 Paper

Role of dynamic changes in blood perfusion and optical properties in thermal coagulation of the prostate

Beop-Min Kim, Steven Jacques, Sohi Rastegar, Sharon Thomsen, Massoud Motamedi

Proceedings Volume 2391, (1995) https://doi.org/10.1117/12.209911

KEYWORDS: Optical properties, Blood, Prostate, Tissue optics, Laser tissue interaction, Blood circulation, Tissues, Scattering, Light scattering, Optical simulations

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Proceedings Article | 12 May 1995 Paper

Oxidatively modified low-density lipoprotein in mononuclear cells detected by laser-induced fluorescence spectroscopy

Tami Glenn, Alexander Oraevsky, Frank Tittel, Sharon Thomsen, Steven Jacques, Philip Henry

Proceedings Volume 2395, (1995) https://doi.org/10.1117/12.209122

KEYWORDS: Luminescence, Fluorescence spectroscopy, Spectroscopy, Blood, Solids, Foam, Laser spectroscopy, Receptors, Laser induced fluorescence, Excimer lasers

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Proceedings Article | 12 May 1995 Paper

Importance of wound stabilization in early wound healing of laser skin welds

Sharon Thomsen, Eric Chan, Ingrid Stubig, Thomas Menovsky, Ashley Welch

Proceedings Volume 2395, (1995) https://doi.org/10.1117/12.209136

KEYWORDS: Wound healing, Skin, Tissues, Laser stabilization, Semiconductor lasers, Continuous wave operation, Laser bonding, Blood, Laser irradiation, Laser welding

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Proceedings Article | 12 May 1995 Paper

Controlled temperature tissue fusion: Ho:YAG laser welding of rat intestine in vivo

Inci Cilesiz, Eric Chan, Ashley Welch, Sharon Thomsen

Proceedings Volume 2395, (1995) https://doi.org/10.1117/12.209141

KEYWORDS: Laser tissue interaction, Laser welding, Feedback control, Tissues, Patents, Intestine, In vivo imaging, Camera shutters, Laser irradiation, Natural surfaces

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Proceedings Article | 8 May 1995 Paper

Optical techniques for diagnosis of cervical precancers: a comparison of Raman and fluorescence spectroscopies

Anita Mahadevan-Jansen, Nirmala Ramanujam, Michele Follen-Mitchell, Anais Malpica, Sharon Thomsen, Rebecca Richards-Kortum

Proceedings Volume 2388, (1995) https://doi.org/10.1117/12.208469

KEYWORDS: Tissues, Raman spectroscopy, Luminescence, Algorithm development, Calibration, Inflammation, Diagnostics, In vivo imaging, Rhodamine, Fluorescence spectroscopy

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Proceedings Article | 18 January 1995 Paper

Pathology of laser tissue welding

Sharon Thomsen, John Austin, Inci Cilesiz, Eric Chan, John Pearce, Ashley Welch, Thomas Menovsky

Proceedings Volume 2323, (1995) https://doi.org/10.1117/12.199186

KEYWORDS: Laser tissue interaction, Tissues, Collagen, Laser welding, Tissue optics, Control systems, Blood, Natural surfaces, Laser bonding, Surgery

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Proceedings Article | 18 January 1995 Paper

Evaluation of a time-resolved stress detection method to determine tissue optical properties

Helene Vijverberg, Sharon Thomsen, Steven Jacques, Alexander Oraevsky

Proceedings Volume 2323, (1995) https://doi.org/10.1117/12.199209

KEYWORDS: Optical properties, Integrating spheres, Skin, Absorption, Tissue optics, Signal attenuation, Tissues, Acoustics, Laser tissue interaction, Scattering

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Proceedings Article | 4 January 1995 Paper

In vivo fluorescence spectroscopy for the diagnosis of skin diseases

Hericus Sterenborg, Massoud Motamedi, R. Wagner, Sharon Thomsen, Steven Jacques

Proceedings Volume 2324, (1995) https://doi.org/10.1117/12.198740

KEYWORDS: Skin, Luminescence, Tumors, Skin cancer, Diagnostics, In vivo imaging, Cancer, Optical fibers, Fluorescence spectroscopy, Optical filters

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Proceedings Article | 7 September 1994 Paper

Comparison of Ho:YAG, Tm:YAG, and argon lasers for fusion of intestinal tissues

John Pearce, Inci Cilesiz, Ashley Welch, Eric Chan, Tom McMurray, Sharon Thomsen

Proceedings Volume 2128, (1994) https://doi.org/10.1117/12.184938

KEYWORDS: Tissues, Thermal modeling, Birefringence, Natural surfaces, Temperature metrology, Collagen, Argon ion lasers, Laser welding, Absorption, Fused deposition modeling

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Proceedings Article | 17 August 1994 Paper

Optical properties of albino rat skin heated in vitro: comparison of photoacoustic and integrating sphere measurement techniques

Sharon Thomsen, Helene Vijverberg, Steven Jacques, Alexander Oraevsky

Proceedings Volume 2134, (1994) https://doi.org/10.1117/12.182924

KEYWORDS: Skin, Optical properties, Absorption, In vitro testing, Integrating spheres, Scattering, Photoacoustic spectroscopy, Signal attenuation, Transmittance, Neodymium

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Proceedings Article | 19 July 1994 Paper

In vitro cellular effects of -aminolevulinic acid sensitized photodynamic therapy

Xiao-Yan He, Steven Jacques, Sharon Thomsen

Proceedings Volume 2133, (1994) https://doi.org/10.1117/12.179989

KEYWORDS: Photodynamic therapy, In vitro testing, Biology, Absorbance, Optical testing, Cell death, Microelectromechanical systems, Toxicity, Cancer, Carbon dioxide

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Proceedings Article | 12 July 1994 Paper

Temperatures associated with thermally induced red blood cell changes in tissues irradiated in vivo

Sharon Thomsen, Jon Schwartz, Rachel Joseph, John Pearce, Brian Rae, Tom McMurray

Proceedings Volume 2130, (1994) https://doi.org/10.1117/12.179925

KEYWORDS: Tissues, Temperature metrology, Blood, Liver, Natural surfaces, In vivo imaging, Thermography, Calibration, Blood circulation, Black bodies

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Proceedings Article | 7 July 1993 Paper

Changes in optical properties of rat skin during thermal coagulation

Sharon Thomsen, Helene Vijverberg, Robert Huang, Jon Schwartz

Proceedings Volume 1882, (1993) https://doi.org/10.1117/12.147663

KEYWORDS: Skin, Temperature metrology, Optical properties, Absorption, In vitro testing, Tissue optics, Control systems, Collagen, Laser scattering, Light scattering

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Proceedings Article | 1 July 1993 Paper

Kinetics for birefringence changes in thermally coagulated rat skin collagen

John Pearce, Sharon Thomsen, Helene Vijverberg, Tom McMurray

Proceedings Volume 1876, (1993) https://doi.org/10.1117/12.147029

KEYWORDS: Birefringence, Collagen, Tissues, Skin, Temperature metrology, Microscopy, In vitro testing, Data fusion, Polarizers, Aluminum

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Proceedings Article | 23 June 1993 Paper

Quantitative morphologic markers of laser thermal injury in cardiovascular tissue

Sharon Thomsen

Proceedings Volume 1878, (1993) https://doi.org/10.1117/12.146579

KEYWORDS: Tissues, Blood, Injuries, In vivo imaging, Collagen, Blood circulation, In vitro testing, Liver, Laser tissue interaction, Head

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Proceedings Article | 18 June 1993 Paper

Photodynamic therapy-induced programmed cell death in carcinoma cell lines

Xiao-Yan He, Robert Sikes, Sharon Thomsen, L. Chung, Steven Jacques

Proceedings Volume 1881, (1993) https://doi.org/10.1117/12.146321

KEYWORDS: Photodynamic therapy, Cell death, Cancer, Tumor growth modeling, Lung, Proteins, Tumors, Oxygen, Plasma, Analytical research

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Proceedings Article | 7 August 1992 Paper

Liver photocoagulation with diode laser (805 nm) versus Nd:YAG (1064 nm)

Steven Jacques, Sohi Rastegar, Massoud Motamedi, Sharon Thomsen, Jon Schwartz, Jorge Torres, Ilkka Mannonen

Proceedings Volume 1646, (1992) https://doi.org/10.1117/12.137451

KEYWORDS: Liver, Blood, Absorption, Semiconductor lasers, Nd:YAG lasers, Laser tissue interaction, Scattering, Optical properties, In vivo imaging, Natural surfaces

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Proceedings Article | 1 June 1992 Paper

Kinetic models of tissue fusion processes

John Pearce, Sharon Thomsen

Proceedings Volume 1643, (1992) https://doi.org/10.1117/12.137349

KEYWORDS: Tissues, Collagen, Thermal modeling, Arteries, Laser tissue interaction, Natural surfaces, Data modeling, Fused deposition modeling, Optical simulations, Laser therapeutics

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Proceedings Article | 1 June 1991 Paper

Changes in collagen birefringence: a quantitative histologic marker of thermal damage in skin

Sharon Thomsen, Wai-Fung Cheong, John Pearce

Proceedings Volume 1422, (1991) https://doi.org/10.1117/12.43938

KEYWORDS: Collagen, Birefringence, Tissues, Skin, Dermatology, Microscopy, Laser welding, Laser marking, Molecules, Transmission electron microscopy

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Proceedings Article | 1 June 1991 Paper

Kinetic models for coagulation processes: determination of rate coefficients in vivo

John Pearce, Wai-Fung Cheong, Kirit Pandit, Tom McMurray, Sharon Thomsen

Proceedings Volume 1422, (1991) https://doi.org/10.1117/12.43937

KEYWORDS: Tissues, Skin, In vivo imaging, Temperature metrology, Thermal modeling, Process modeling, Molecules, Dermatology, Laser irradiation, Thermography

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Proceedings Article | 1 June 1991 Paper

Histopathologic assessment of water-dominated photothermal effects produced with laser irradiation

Sharon Thomsen, Wai-Fung Cheong, John Pearce

Proceedings Volume 1422, (1991) https://doi.org/10.1117/12.43935

KEYWORDS: Tissues, Laser irradiation, Photothermal effect, Laser ablation, Natural surfaces, Dermatology, Explosives, Diffusion, Collagen, Water

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Proceedings Article | 1 May 1991 Paper

Practical and theoretical considerations on the use of quantitative histology to measure thermal damage of collagen in cardiovascular tissues

Sharon Thomsen

Proceedings Volume 1425, (1991) https://doi.org/10.1117/12.44042

KEYWORDS: Collagen, Tissues, Birefringence, Blood vessels, Laser marking, Injuries, Thermal effects, Laser irradiation, Image transmission, Microscopy

Proceedings Article | 1 June 1990 Paper

Microscopic correlates of macroscopic optical property changes during thermal coagulation of myocardium

Sharon Thomsen, Steven Jacques, Stephen Flock

Proceedings Volume 1202, (1990) https://doi.org/10.1117/12.17605

KEYWORDS: Scattering, Mie scattering, Tissues, Proteins, Laser scattering, Light scattering, Optical properties, Thermal effects, Absorption, Laser tissue interaction

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Showing 5 of 70 publications

Proceedings Volume Editor (2)

SPIE Conference Volume | 1 July 1998

Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VIII

SPIE Conference Volume | 1 July 1998

Lasers in Surgery: Advanced Characterization, Therapeutics, and Systems VIII

Conference Committee Involvement (14)

Energy-based Treatment of Tissue and Assessment IX

29 January 2017 | San Francisco, California, United States

Energy-based Treatment of Tissue and Assessment VIII

8 February 2015 | San Francisco, California, United States

Energy-Based Treatment of Tissue and Assessment VII

3 February 2013 | San Francisco, California, United States

Energy-based Treatment of Tissue and Assessment VI

23 January 2011 | San Francisco, California, United States

Energy-based Treatment of Tissue and Assessment V

26 January 2009 | San Jose, California, United States

Showing 5 of 14 Conference Committees

Course Instructor

SC692: Non-Ionizing Irradiation Interactions with Biologic Tissue

The immediate and delayed effects of the interactions of non-ionizing irradiation with biologic materials are determined by their anatomic organization, physiology, chemical composition and physical properties. Qualitative and quantitative pathologic analytic methods including 1) gross and microscopic anatomic analyses and 2) histochemistry and immunohistochemistry will be described and discussed as important investigational tools. These methods can be used to 1) identify normal and abnormal tissues. 2) identify experimental end points characteristic of the irradiation/tissue interactions, 3) determine the mechanisms of irradiation/tissue interaction effects, 4) map the extent and severity of the effects and 5) display the dynamics of irradiation effects and delayed tissue reactions over time. Lastly, practical instructions for preparing biologic materials for pathologic examination will be presented.

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